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Frost & Sullivan Recognizes ESBATech's Innovation in Developing Antibody Fragments for Biologic Therapeutics
Date:1/26/2009

ire high drug affinity and specificity, but do not require an immune effector response. ESBA105, the company's lead product candidate, is a recombinant humanized scFv non-aggregating antibody fragment being evaluated in treating a number of indications including ocular disease.

ESBA105 is directed against human TNF alpha - a cytokine that has been identified as the cause of many inflammatory conditions including uveitis, a group of inflammatory diseases affecting the uvea. To date, the only class of drugs approved to treat uveitis is corticosteroids, which are often associated with serious side effects such as cataract and glaucoma hypertension, and in many instances must be dosed up to 16 times a day.

However, topical corticosteroids only show limited intraocular penetration, and in severe disease cases they frequently require periocular injections or even systemic immunosuppressive therapy. In contrast, in preclinical in vivo testing, high concentrations of ESBA105 were achieved in all segments of the eye when administered topically through eye drops. As anterior uveitis accounts for up to 90 percent of all cases of uveitis, FDA approval of ESBA105 - which, pending favorable clinical studies the company anticipates could come as soon as 2012 - will undoubtedly offer those with this disease a much needed and much more convenient treatment.

"The ability of ESBATech's innovative antibody fragments to improve clinical effects as compared to typical monoclonal antibody therapies, offers the company limitless possibilities in advancing and improving treatment options for not only ocular diseases, but numerous disease targets," notes Hughes. "The company's antibody fragment's unique capacity to topically and locally deliver high drug concentrations to targeted sites, coupled with strikingly low systemic load and the resulting lowered risk of drug interactions, puts it at the forefront of innovation ushering in a new era
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SOURCE Frost & Sullivan
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