Navigation Links
Frost & Sullivan Recognizes ESBATech's Innovation in Developing Antibody Fragments for Biologic Therapeutics

MOUNTAIN VIEW, Calif., Jan. 26 /PRNewswire/ -- Based on its recent analysis of the ophthalmic pharmaceuticals market, Frost & Sullivan recognizes ESBATech with the 2009 North American Frost & Sullivan Technology Innovation of the Year Award for its work in developing antibody fragments. The smaller size of ESBATech's proprietary single-chain antibody fragment therapeutics addresses and overcomes many of the challenges associated with whole antibodies when treating diseases of the eye.


Unlike monoclonal antibodies that contain the Fc part of the antibody that triggers immune responses, antibody fragments consist of only the naturally occurring antigen-binding pocket of the monoclonal antibody. This can be advantageous for disease indications such as age-related macular degeneration (AMD) and uveitis, where no immune response is required. For this reason, endogenous proteins make excellent targets for these novel biologics.

"While antibody fragments are an appealing new therapy class, limitations such as poor production yields due to low stability, immunogenicity due to their high proclivity to aggregate, and a short half-life in the blood stream have hindered their success in preclinical and clinical trials," says Frost & Sullivan Research Analyst Misty Hughes. "In response, ESBATech developed its cutting-edge, repeatable-antigen independent screening platform, Immuna(R), for selecting and optimizing highly-stable, single-chain antibody fragments (scFv) without any phage display."

ESBATech's successful screening and characterization of all 1.5 million naturally occurring antibody fragment frameworks resulted in highly-stable, single-chain antibody fragments. These drug-like fragments are ideal for pioneering therapeutic interventions that require high drug affinity and specificity, but do not require an immune effector response. ESBA105, the company's lead product candidate, is a recombinant humanized scFv non-aggregating antibody fragment being evaluated in treating a number of indications including ocular disease.

ESBA105 is directed against human TNF alpha - a cytokine that has been identified as the cause of many inflammatory conditions including uveitis, a group of inflammatory diseases affecting the uvea. To date, the only class of drugs approved to treat uveitis is corticosteroids, which are often associated with serious side effects such as cataract and glaucoma hypertension, and in many instances must be dosed up to 16 times a day.

However, topical corticosteroids only show limited intraocular penetration, and in severe disease cases they frequently require periocular injections or even systemic immunosuppressive therapy. In contrast, in preclinical in vivo testing, high concentrations of ESBA105 were achieved in all segments of the eye when administered topically through eye drops. As anterior uveitis accounts for up to 90 percent of all cases of uveitis, FDA approval of ESBA105 - which, pending favorable clinical studies the company anticipates could come as soon as 2012 - will undoubtedly offer those with this disease a much needed and much more convenient treatment.

"The ability of ESBATech's innovative antibody fragments to improve clinical effects as compared to typical monoclonal antibody therapies, offers the company limitless possibilities in advancing and improving treatment options for not only ocular diseases, but numerous disease targets," notes Hughes. "The company's antibody fragment's unique capacity to topically and locally deliver high drug concentrations to targeted sites, coupled with strikingly low systemic load and the resulting lowered risk of drug interactions, puts it at the forefront of innovation ushering in a new era in medicine."

In recognition of these innovations in biotechnology, Frost & Sullivan is pleased to present ESBATech with the 2009 Technology Innovation of the Year Award in the ophthalmic pharmaceuticals market. Each year, this award is presented to a company that has demonstrated technological superiority within its industry. The award acknowledges the ability of the company to successfully develop and introduce new technology, formulate a well-designed product family, and make significant product performance contributions to the industry.

Frost & Sullivan's Best Practices Awards recognize companies in a variety of regional and global markets for demonstrating outstanding achievement and superior performance in areas such as leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analysis, and extensive secondary research in order to identify best practices in the industry.

About ESBATech

ESBATech is a clinical-stage biotechnology company concentrating its research in developing and commercializing fully human single-chain antibody fragments and formulation technologies to safely and non-invasively deliver biologic therapeutics. The company was the first to non-invasively deliver an ophthalmic biologic drug via eye drops elucidating a depot effect in the eye's vitreous. ESBATech's lead antibody fragment, ESBA105, is in clinical trials for several indications including uveitis, an inflammatory condition responsible for an estimated 10 to 15 percent of all cases of blindness in the Unites States. The company recently completed a phase I clinical study of ESBA105, and is now in preparation for phase II trials.

About Frost & Sullivan

Frost & Sullivan, the Growth Partnership Company, enables clients to accelerate growth and achieve best in class positions in growth, innovation and leadership. The company's Growth Partnership Service provides the CEO and the CEO's Growth Team with disciplined research and best practice models to drive the generation, evaluation and implementation of powerful growth strategies. Frost & Sullivan leverages over 45 years of experience in partnering with Global 1000 companies, emerging businesses and the investment community from 31 offices on six continents. To join our Growth Partnership, please visit

    Jake Wengroff

SOURCE Frost & Sullivan
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. Ganeden Biotech Receives Frost & Sullivan Probiotics Product Innovation Award
2. Frost & Sullivan Commends Honeywell Enraf for Cutting-Edge Products and Post-Sales Support
3. Frost & Sullivan Recognizes Martek Biosciences for Unique and Customer-Focused Strategies With Customer Value Enhancement Award
4. Frost & Sullivan Awards Baxters BioPharma Solutions Business the 2008 North American Customer Service Leadership of the Year Award
5. Frost & Sullivan Presents CorMatrix Cardiovascular Inc. with 2008 Healthcare Innovation Award for the Treatment of Cardiovascular Disease
6. Aposense Receives Frost & Sullivan Technology Innovation of the Year Award
7. Frost & Sullivan Awards Genpathway 2008 Healthcare Innovation Award
8. Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan
9. Frost & Sullivan Acknowledges ISTO Technologies Role in Developing Advanced Biologic Products for Bone Healing
10. Small Animal Imaging Market: Biospace Lab Wins Frost & Sullivan Accolade for Its Successful Product Line Strategy
11. Celsis Receives Frost & Sullivan 2008 Best Practices Award
Post Your Comments:
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( ), finds that the market earned ...
(Date:11/24/2015)... ... 24, 2015 , ... Copper is an essential micronutrient that ... proteins, copper is also toxic to cells. With a $1.3 million award from ... conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions leader SAP and ... to develop and pitch their BIG ideas to improve health and wellness in their ... votes to win the title of SAP's Teen Innovator, an all-expenses paid trip to ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris ... today that the remaining 11,000 post-share consolidation (or ... Warrants (the "Series B Warrants") subject to the ... on November 23, 2015, which will result in ... giving effect to the issuance of such shares, ...
Breaking Biology Technology:
(Date:10/29/2015)... Oct. 29, 2015  Rubicon Genomics, Inc., today ... distribution of its DNA library preparation products, including ... new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has been ... of NGS libraries for liquid biopsies--the analysis of ... prognostic applications in cancer and other conditions. Eurofins ...
(Date:10/29/2015)... , Oct. 29, 2015 Today, ... announced a partnership with 2XU, a global leader ... deliver a smart hat with advanced bio-sensing technology. ... other athletes to monitor key biometrics to improve ... strategic partnership, the two companies will bring together the ...
(Date:10/27/2015)... Calif. , Oct. 27, 2015 Synaptics Inc. ... solutions, today announced that Google has adopted the Synaptics ... touch controller solutions to power its newest flagship smartphones, ... by Huawei. --> ... like Google to provide strategic collaboration in the joint ...
Breaking Biology News(10 mins):