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Frost & Sullivan Acknowledges ISTO Technologies' Role in Developing Advanced Biologic Products for Bone Healing
Date:10/14/2008

MOUNTAIN VIEW, Calif., Oct. 14 /PRNewswire/ -- Based on its recent analysis of the bone healing market, Frost & Sullivan recognizes ISTO Technologies, Inc. with the 2008 North American Frost & Sullivan Award for Product Innovation for its novel InQu(R) Bone Graft Extender and Substitute scaffold. InQu represents the first commercial product launched by the company using its proprietary biomaterial-based platform technology.

Although spinal fusions and other orthopedic intervention methods are routinely used to eliminate back pain, surgeons are still unsure about the right choice in bone grafting materials. While autologous grafts have traditionally been considered the "gold standard" in treatment, the pain associated with harvesting autologous bone, along with an increase in operation and recovery times, and high rates of complications including donor site morbidity have made a case for alternative treatments.

"ISTO Technologies' InQu Bone Graft Extender and Substitute brings to the forefront the strengths and biological attributes of two reliable, safe, and effective biomaterials: Poly lactide-co-glycolide (PLGA) and hyaluronic acid (HyA)," explains Frost & Sullivan Research Analyst Pramodh Ishwarakrishnan. "The unique InQu scaffold creates a microenvironment that is both biocompatible and conducive to new bone formation."

These two major components of the scaffold have specific contributions to the overall healing process. PLGA, while giving the three-dimensional structure to InQu, also provides a reliable resorption rate at the site of implantation. HyA has been shown to play a critical role in tissue regeneration and repair, apart from promoting the migration, proliferation, and differentiation of osteogenic cells during the early stages of normal bone formation.

"The ideal combination of PLGA and HyA offers the advantages of superior cohesiveness, molding properties, handling characteristics and consistently predictable result
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