Navigation Links
Foundation Venture Capital Group Portfolio Company Identifies FRY Gene As Breast Cancer Susceptibility Suppressor
Date:10/28/2013

ether there were chromosomal regions that conferred resistance to the offspring. This genetic linkage analysis identified a region on rat chromosome 12 within a region that is conserved on human chromosome 13. This region also contains the BRCA2 breast cancer suppressor gene.

"After ruling out the BRCA2 gene, we found that FRY, a gene immediately adjacent to the rat BRCA2 suppressor gene, was mutated in the susceptible F344 strain," said Dr. Zarbl.  "Studies further showed that FRY was reduced in all human breast cancer cell lines examined as a result of decreased expression or mutation."

These findings are the basis for ongoing studies now assessing the role of the FRY gene in cancer susceptibility and progression.

"Dr. Zarbl's findings suggest that FRY could potentially be used as a platform to develop cancer gene-based susceptibility tests, for disease progression and for tumor grading," explained Dr. George F. Heinrich, Foundation Venture Capital Group vice chair and CEO. "This tumor suppressor gene could be useful for developing new targeted drugs, especially for the treatment of aggressive and/or advanced breast cancer."

For more information, contact James M. Golubieski, president of FVCG, at (908) 731-6601 or at jgolubieski@njhf.org

About Foundation Venture Capital Group

Foundation Venture Capital Group, LLC, (www.foundationventure.com) invests in start-up companies in the life sciences field that want to move their products and ideas to commercialization. FVCG portfolio companies currently include: 

  • Actinobac Biomed Inc., developing a therapeutic agent targeting blood cells for the treatment of hematological malignancies such as leukemia and lymphomas;
  • Affineti Biologics, I
    '/>"/>

SOURCE Foundation Venture Capital Group
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. BMJ and the Lupus Foundation of America to Publish Lupus Science & Medicine, the First Open Access Journal Dedicated to Lupus
2. The Galien Foundation Honors Excellence in Scientific Innovation and Humanitarian Efforts at 2013 Prix Galien USA Awards Gala
3. Agile and Scrum Workshop – Values, Foundations, and Practices in San Diego, CA by Conscires Agile Practices
4. “Agile and Scrum – Values, Foundations, and Practices” in Philadelphia, PA- 8 PDUs
5. Proove CEO and Vice Chairman of the Howard County Board of Education, Brian Meshkin, Selected as one of Howard County's Finest Under 39 by the Cystic Fibrosis Foundation
6. Bayer CropScience and the Florida Specialty Crop Foundation Join Together to Fight Citrus Greening
7. La Allotrope Foundation se asocia con Osthus Inc.
8. Allotrope Foundation partners with Osthus Inc. to develop state-of-the-art open framework for laboratory data
9. Chicago Mayor Rahm Emmanuel and Illinois Governor Patrick Quinn Recognize Brain Research Foundations 60th Anniversary
10. Avon Foundation for Women, NIH, and the Center for Advancing Innovation Launch Start-Up Challenge to Advance Breast Cancer Biomedical Invention
11. The tranSMART Foundation Announces New Version of the tranSMART Open Source Data Sharing Platform for the Life Sciences Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2015)... April 16, 2015  Scientists from Cleave Biosciences will ... the Horizon," at the American Association for Cancer Research ... on Sunday, April 19, 2015 from 3:15pm to ... of Biology, will present new in vivo and mechanism ... inhibitor of p97, a critical enzyme that controls various ...
(Date:4/16/2015)... , April 16, 2015  EMD Serono today ... Darmstadt, Germany , appointed ... Head of Global Clinical Development.  Dr. Reicin brings ... experience in Oncology and Immunology. She is an ... served as a Vice President in various capacities ...
(Date:4/16/2015)... Columbia and MENLO PARK, Calif. ... Inc. (OTCQX: DMPI) (DelMar and the Company), a ... therapies in new orphan drug indications, today announced that ... added as a clinical trial site for the ongoing, ... refractory glioblastoma multiforme (GBM), the most common and deadly ...
(Date:4/16/2015)... Md. , April 16, 2015  Northwest ... a biotechnology company developing non-toxic DCVax® personalized immune ... been included in the Loncar Cancer Immunotherapy Index ... investors better track the immunotherapy field within the ... have selected "the top 25 companies" in the ...
Breaking Biology Technology:Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 2DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 4DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 5NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3
... managed, with the help of an advanced X-ray flash, to ... that has been recognised by the journal Science . ... home to one of the world,s most advanced particle accelerators, ... and study life,s tiniest components: atoms, molecules and proteins. ...
... PLYMOUTH MEETING, Pa. , May 10 /PRNewswire-Asia-FirstCall/ -- ... announced,financial results for the first quarter ended March 31, 2010 . ... ... was a,quarter of successful management transition at Sunstone. We replaced senior,managers including ...
... Fla. , May 10 Dyadic International, Inc. ... today that its President and Chief Executive Officer, Mark ... Renshaw 6th Annual Global Healthcare Conference in London, England ... 11:05 a.m. local time ( 6:05 a.m. EDT ). ...
Cached Biology Technology:BMP Sunstone Reports First Quarter 2010 Financial Results 2BMP Sunstone Reports First Quarter 2010 Financial Results 3BMP Sunstone Reports First Quarter 2010 Financial Results 4BMP Sunstone Reports First Quarter 2010 Financial Results 5BMP Sunstone Reports First Quarter 2010 Financial Results 6BMP Sunstone Reports First Quarter 2010 Financial Results 7BMP Sunstone Reports First Quarter 2010 Financial Results 8BMP Sunstone Reports First Quarter 2010 Financial Results 9BMP Sunstone Reports First Quarter 2010 Financial Results 10BMP Sunstone Reports First Quarter 2010 Financial Results 11BMP Sunstone Reports First Quarter 2010 Financial Results 12Dyadic International to Present at Rodman & Renshaw 6th Annual Global Healthcare Conference 2
(Date:3/31/2015)... YORK , March 31, 2015  Elephant Talk ... "Company"), a global provider of Software Defined Network Architecture ... today announced total revenue of approximately $20.4 million for ... a restated $19.5 million for the year ended December ... calendar 2014, the Company had completed its multi-year transition ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... Scientists at IRB Barcelona have discovered that some brain ... use the genetic programme of germline cells to grow. ... brains. This finding demonstrates that these genes are crucial for ... is published today in the prestigious journal Science . ...
... study was carried out to examine the extent ... or insulin resistance in primary cultures of human ... cytokine elevated in the plasma and adipose tissue ... adipocytes were pretreated with quercetin and trans-RSV followed ...
... have succeeded in plugging a metal atom into a ... could be a key in opening up new production ... of organic compounds, which in turn might have implications ... is the first to determine the precise structure of ...
Cached Biology News:Some brain tumors mimic the genetic program of germline cells 2Study on effects of resveratrol and quercetin on inflammation and insulin resistance 2Milestone: A methane-metal marriage 2Milestone: A methane-metal marriage 3Milestone: A methane-metal marriage 4
... P815 cells were cultured in DMEM and harvested ... order to keep the antigens in their native ... cells are arrayed on a 12-well (5 mm) ... treated to enhance cellular attachment and to minimize ...
... / 3T3 cells were cultured in DMEM with ... phase of growth. In order to keep ... fixed in acetone-methanol. The cells are arrayed ... with each wells surface specifically treated to enhance ...
Miscellaneous: Versatile stain for staining RNA (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides Assay: ~ 95 % Suitab tst: differential staining of nucleic acids and prote...
... EPICENTREs patented MasterAmp™ 10X PCR ... performance and allows improved sensitivity and ... templates. Using MasterAmp PCR Enhancer in ... of DNA melting, increases enzyme?s thermal ...
Biology Products: