NEW BRUNSWICK, N.J., Oct. 28, 2013 /PRNewswire-USNewswire/ -- Researchers from GeneAssess, Inc., a Foundation Venture Capital Group portfolio company, announce the publication of the genetic studies that led to the identification of the FRY gene as a breast cancer susceptibility suppressor gene.
"We see great promise in Dr. Zarbl's discovery of the FRY gene and how it might be used to affect the diagnosis and treatment of aggressive breast cancers," noted James M. Golubieski, president of Foundation Venture Capital Group. "We are excited about helping to advance his work and bring his ideas to commercialization."
The studies, which appear in the online journal PLOS ONE (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0070930), are the culmination of more than 12 years of research performed by Dr. Helmut Zarbl, founder of GeneAssess, Inc.
"The current focus of GeneAssess is dedicated to the discovery, development and commercialization of novel high value diagnostic tests that help physicians diagnose, treat and improve outcomes for cancer patients," explained Dr. Zarbl, who is also a professor of environmental and occupational medicine at Rutgers Robert Wood Johnson Medical School and the associate director for the Public Health Sciences Division at The Rutgers Cancer Institute of New Jersey.
The studies featured in PLOS ONE examined why some rat strains are almost completely resistant to cancer, while other strains develop mammary carcinomas at a very high frequency when exposed to chemical carcinogens, hormones or radiation during the onset of puberty. To find the genes underlying this difference, Dr. Zarbl and his research team performed genetic crosses between a sensitive and resistant strain and examined whether there were chromosomal regions that conferred resistance to the offspring. This genetic linkage analysis identified a region on rat chromosome 12 within a region that is conserved on human chromosome 13. This region also contains the BRCA2 breast cancer suppressor gene.
"After ruling out the BRCA2 gene, we found that FRY, a gene immediately adjacent to the rat BRCA2 suppressor gene, was mutated in the susceptible F344 strain," said Dr. Zarbl. "Studies further showed that FRY was reduced in all human breast cancer cell lines examined as a result of decreased expression or mutation."
These findings are the basis for ongoing studies now assessing the role of the FRY gene in cancer susceptibility and progression.
"Dr. Zarbl's findings suggest that FRY could potentially be used as a platform to develop cancer gene-based susceptibility tests, for disease progression and for tumor grading," explained Dr. George F. Heinrich, Foundation Venture Capital Group vice chair and CEO. "This tumor suppressor gene could be useful for developing new targeted drugs, especially for the treatment of aggressive and/or advanced breast cancer."
For more information, contact James M. Golubieski, president of FVCG, at (908) 731-6601 or at firstname.lastname@example.org.
About Foundation Venture Capital Group
Foundation Venture Capital Group, LLC, (www.foundationventure.com) invests in start-up companies in the life sciences field that want to move their products and ideas to commercialization. FVCG portfolio companies currently include:
|SOURCE Foundation Venture Capital Group|
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