Navigation Links
Football-shaped particles bolster the body's defense against cancer
Date:10/19/2013

ivalent densities and mixed with T-cells in the laboratory the T-cells multiplied many more times in response to the stretched particles than to spherical ones. In fact, by stretching the original spheres to varying degrees, they found that, up to a point, they could increase the multiplication of the T-cells just by lengthening the "footballs."

When the particles were injected into mice with skin cancer, the T-cells that interacted with the elongated artificial APCs, versus spherical ones, were also more successful at killing tumor cells. Schneck says that tumors in mice that were treated with round particles reduced tumor growth by half, while elongated particles reduced tumor growth by three-quarters. Even better, he says, over the course of a one-month trial, 25 percent of the mice with skin cancer being treated with elongated particles survived, while none of the mice in the other treatment groups did.

According to Green, "This adds an entirely new dimension to studying cellular interactions and developing new artificial APCs. Now that we know that shape matters, scientists and engineers can add this parameter to their studies," says Green. Schneck notes, "This project is a great example of how interdisciplinary science by two different groups, in this case one from biomedical engineering and another from pathology, can change our entire approach to tackling a problem. We're now continuing our work together to tweak other characteristics of the artificial APCs so that we can optimize their ability to activate T-cells inside the body."


'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Microparticles and Applications in Assays and Endpoints, New Life Science Webinar Hosted by Xtalks
2. Researchers use nanoparticles to deliver vaccines to lungs
3. UCLA researchers smartphone microscope can detect a single virus, nanoparticles
4. New nanoparticles make solar cells cheaper to manufacture
5. Gold nanoparticles improve photodetector performance
6. Light particles illuminate the vacuum
7. Penn researchers develop protein passport that help nanoparticles get past immune system
8. Widely used nanoparticles enter soybean plants from farm soil
9. Nanoparticles digging the worlds smallest tunnels
10. New information on binding gold particles over metal oxide surfaces
11. Lung mucus gel scaffold prevents nanoparticles from getting through
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Football-shaped particles bolster the body's defense against cancer
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 /PRNewswire/ ... company advancing patient care in critical areas, announced the ... of common stock, and warrants to purchase up to ... offering price of $4.00 per share and $.01 per ... of $5.00, are exercisable immediately, and expire 5 years ...
(Date:12/24/2014)... 2014 “Preparative & Process Chromatography ... Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, ... - Forecasts to 2019” provides a detailed overview ... market trends, and strategies impacting the preparative and ... forecasts of the revenue and share analysis. ...
(Date:12/24/2014)... SoundConnect’s 2015 ... introduce cutting edge communication technology, provide continued ... platform upgrades. This webinar series demonstrates online ... their quest to leverage web conferencing’s most ... SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our webinars ...
(Date:12/24/2014)... The report provides basic ... definition, classification, application and industry overview. This ... and product cost structure. Production is separated ... also covers upstream raw materials, equipment, downstream ... and proposals. In the end, the export ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... ... Abstracts Service (CAS), the global expert on chemical information, reports that China,s ... in chemistry. China trailed Japan,s patent office, the World Intellectual Property Organization ... than a decade, but passed the USPTO in 2005, WIPO in 2006, ...
... of a two-dimensional carbon layer in which the ... resembling a honeycomb. Carbon nanotubes are rolled-up sheets ... form graphite. Graphene boasts some very special characteristics ... conductor, and reconciles such conflicting qualities as brittleness ...
... , SEATTLE, Nov. 23 Immune Design Corp. (IDC) announced ... Executive Chairman. Dr. Carter has a successful track record ... Executive Officer at ZymoGenetics, in Seattle, WA and Chief Scientific ... http://www.newscom.com/cgi-bin/prnh/20091123/SF15228 ) , Dr. Steven Reed, IDC,s founder and ...
Cached Biology Technology:China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3Polymer with honeycomb structure 2Immune Design Corp. Announces Appointment of Dr. Bruce L.A. Carter as Executive Chairman and Director 2
(Date:12/10/2014)... 9, 2014 CIE San Diego has launched ... the connective tissue that enhances care coordination among social ... share client-level information; earned a second $1 million grant ... serving seniors aging in community and; will be recognized ... 11 th 4-6p. CIE San Diego ...
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... 2014 Strict laws against distracted driving and ... North American and European automotive sector towards gesture recognition ... systems that are intuitive and able to retrieve information ... New analysis from Frost & Sullivan,s ... Europe and North ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... the sixth most common type of cancer and is on ... any known risk factors. Now, researchers at Fox Chase Cancer ... cells in the mouth and thus promote the spread of ... results, published in the January issue of Cancer Prevention ...
... (Mon., Jan. 3, 2011) -- New technologies and ... organogenesis. Organogenesis, essentially the process through which a ... connections to biological processes at the cellular and developmental ... treatments through tissue engineering approaches. The January issue ...
... An international team of researchers led by Daniel ... Institute for Translational Medicine and Therapeutics, has received ... Leducq to study the molecular genetics of atherosclerotic ... Novel Genes Associated with Plasma Lipids and Cardiovascular ...
Cached Biology News:Estrogen may help precancerous cells spread in oral cavity 2Transcriptome analysis, organ culture methods featured in Cold Spring Harbor Protocols 2Penn Medicine researcher receives $6 million grant for cardiovascular disease study 2
... Fluoroskan Ascent FL ... fluorometric and luminometric measurement ... long list of advanced ... and Luminoskan Ascent. Fluoroskan ...
...
...
... cabinets Heraeus HERAsafe KS convince with an optimum ... new frameless slanted window does not obscure the ... window design makes it easy to work in ... a height of more than 250 mm ensures ...
Biology Products: