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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance

Date:4/25/2008

s where he headed a worldwide development team.

Board succession changes

- The Company confirms that the succession changes announced in December 2007, whereby Matthew Emmens will succeed Dr James H Cavanaugh as the Company's non executive Chairman and Angus Russell will succeed Mr Emmens as the Company's Chief Executive, will take place with effect from June 18, 2008. At this time David Kappler will become Deputy Chairman in addition to his role as Senior Independent Director. Dr Cavanaugh will retire from the Board on June 18, 2008.

Q1 2008 Unaudited Results

Q1 2008 Q1 2007

Non Non

US GAAP Adjustments GAAP(1) US GAAP Adjustments GAAP(1)

$M $M $M $M $M $M

_______ _________ __________ _______ __________ __________

Revenues 702.2 - 702.2 528.2 - 528.2

Operating 163.0 28.8 191.8 141.2 15.3 156.5

income

Net income 128.6 11.0 139.6 112.7 11.2 123.9

Diluted

earnings

per:

Ordinary 22.7c 1.9c 24.6c 21.3c 2.1c 23.4c

ADS 68.1c 5.7c 73.8c 63.9c 6.3c 70.2c

Note: Average exchange rates for Q1 2008 and Q1 2007 were

$1.98:GBP1.00 and $1.95:GBP1.00, respectively.

(1) Non GAAP operating income, Non GAAP net income, Non GAAP diluted earnings per ordinary share and Non GAAP diluted earnings per ADS exclude intangible asset amortization charges and other items as described on page 7. For an explanation of why Shire's management believes that these non GAAP financial measures are useful to investors, see page 7. For a reconciliation of these non GAAP financial measures to the most directly comp
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SOURCE Shire plc
Copyright©2008 PR Newswire.
All rights reserved

1

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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financia...(s where he headed a worldwide developmen...)