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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

ion position, and better facilitate Shire's financial management. Shire believes that the most appropriate structure is for a new group parent company to be tax-resident in the Republic of Ireland.

- It is intended that Shire Limited will be listed on the LSE in Shire's place and Shire Limited ADSs will be traded on NASDAQ in place of the Shire ADSs. The proposal does not involve any payment for the new ordinary shares or ADSs.

- The Scheme will require the approval of Shire ordinary shareholders at a shareholder meeting convened at the direction of the High Court on May 9, 2008 and also separate approval at an extraordinary general meeting of Shire to be held immediately after the Court meeting. Under the anticipated timetable, and subject to shareholder and Court approval, the Scheme will become effective on May 23, 2008.

- Shire Limited will have the same Board and management team as Shire and there will be no substantive changes to corporate governance and investor protection measures. The proposal will not result in any changes in the day to day conduct of the business or its strategy or dividend policy, nor is it planned that the proposal will result in any job losses or relocation of existing Shire personnel out of the UK.

- The first annual shareholder meeting of Shire Limited will be scheduled for September 24, 2008.

- The Company incurred costs associated with the introduction of a new holding company of $5.6 million up to March 31, 2008.

Non-Executive Director

- On April 24, 2008 Shire announced that Michael Rosenblatt M.D. joined the Shire Board as a Non-Executive Director. Dr Rosenblatt is the Dean of Tufts University School of Medicine, Boston, Massachusetts. He was previously Professor of Medicine at Harvard Medical School and has served in senior research positions at the Beth Israel Deaconess Medical Center in Boston and as Senior Vice President for Research at Merck Sharp & Dohme Research Laboratorie
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SOURCE Shire plc
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