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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

ch is conditional upon the receipt of customary consents. Subsequent to closing no royalties or future milestone payments will be due from Shire to Zymenex.

DAYTRANA

- Some patients and caregivers continue to have difficulty removing the release liner of some DAYTRANA patches, similar to the concerns which led to a voluntary market withdrawal of a limited number of DAYTRANA patches in September 2007. Shire and Noven continue to review and monitor release liner complaints and the manufacturing process to determine whether modifications to the product or process can improve the long term ease of use. There is no assurance that there will be a satisfactory resolution to this issue.

FOSRENOL

- Effective April 16, 2008 Shire and Abbott Laboratories Inc. mutually agreed to terminate their Co-Promotion Agreement for FOSRENOL in the United States. Shire will continue to promote FOSRENOL on its own in the United States and throughout Europe.

A new UK listed holding company

- On April 15, 2008 Shire announced a proposed Court sanctioned scheme of arrangement ("Scheme") relating to the corporate structure and organisation of Shire, including the creation of a new London Stock Exchange ("LSE") listed, Jersey incorporated, and Irish tax resident holding company for the group, which is to be called Shire Limited. On April 16, 2008 a circular describing the Scheme was posted to Shire ordinary shareholders and a prospectus in relation to Shire Limited was also published. Both documents are available on Shire's website.

- Through a series of transactions over the last ten years, Shire's business has been transformed, from a primarily UK business to an international business, with the vast majority of its revenues generated from outside the UK. Shire has concluded that its business and its shareholders would be better served by having an international holding company with a group structure that is designed to help protect Shire's taxat
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SOURCE Shire plc
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