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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

The following items are included in Adjustments:

a) Costs associated with the introduction of a new holding company ($5.6 million);

b) Amortization of intangible assets relating to intellectual property rights acquired ($30.8 million);

c) Gains on the disposal of non-core product rights ($7.6 million);

d) Gain on the disposal of a minority equity investment ($9.4 million); and
e) Tax effect of adjustments outlined as (a) to (d).

Unaudited US GAAP results for the three months to March 31, 2007

Non GAAP reconciliation

US GAAP Non GAAP

3 months to 3 months to

March 31, Adjustments March 31,

2008 2008

$M $M $M

Total revenues 528.2 - 528.2

Costs and expenses:

Cost of product sales 65.3 - 65.3

Research and development 79.0 - 79.0

Selling, general and

administrative 213.8 - 213.8

Depreciation and amortization 28.9 (15.3) (a) 13.6

Total operating expenses 387.0 (15.3) 371.7

Operating income
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SOURCE Shire plc
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