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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

$M $M

Total revenues 702.2 - 702.2

Costs and expenses:

Cost of product sales 90.3 - 90.3

Research and development 119.1 - 119.1

Selling, general and

administrative 293.0 (5.6) (a) 287.4

Depreciation and amortization 44.4 (30.8) (b) 13.6

Gain on sale of product rights (7.6) 7.6 (c) -

Total operating expenses 539.2 (28.8) 510.4

Operating income 163.0 28.8 191.8

Interest income 12.7 - 12.7

Interest expense (17.3) - (17.3)

Other income, net 12.7 (9.4) (d) 3.3

Total other income, net 8.1 (9.4) (1.3)

Income before income taxes and

equity in earnings of equity

method investees 171.1 19.4 190.5

Income taxes (44.1) (8.4) (e) (52.5)

Equity in earnings of equity

method investees, net of tax 1.6 - 1.6

Net income 128.6 11.0 139.6

Interest on convertible debt,

net of tax 3.4 - 3.4

Numerator for diluted EPS from

ongoing operations 132.0 11.0 143.0

Weighted average number of

shares (millions) - diluted 581.5 581.5

Diluted earnings per ordinary

share 22.7c 24.6c

Diluted earnings per ADS 68.1c 73.8c
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SOURCE Shire plc
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