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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

e of warrants - 7.0

Payments to acquire shares by employee share

ownership trust ("ESOT") (33.1) (44.3)

Net cash (used in)/provided by financing

activities(C) (33.0) 860.4

Effect of foreign exchange rate changes on cash and

cash equivalents (D) 3.8 1.0

Net increase in cash and cash equivalents(A) +(B)

+(C) +(D) 28.1 919.3

Cash and cash equivalents at beginning of period 762.5 1,126.9

Cash and cash equivalents at end of period 790.6 2,046.2

Unaudited US GAAP results for the three months to March 31, 2008

Selected Notes to the US GAAP Financial Statements

(1) Earnings per share

3 months to March 31, 2008 2007

$M $M

Net income 128.6 112.7

Numerator for basic EPS 128.6 112.7

Interest on convertible bonds, net of tax 3.4 -

Numerator for diluted EPS 132.0 112.7

Weighted average number of shares: Million Million

Basic (1) 545.1 522.6

Effect of dilutive shares:

Stock based awards to employees(2) 3.7 6.4

Warrants(2) - 0.7

Convertible bonds 2.75% due 2014(3) 32.7 -

Diluted 581.5 529.7

(1) Excludes shares purchased by the ESOT and presented by the Company as treasury stock.

(2) Calculated using the treasury stock method.

(3) Calculated using the "if-converted" method.

The share equivalen
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SOURCE Shire plc
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