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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

0.3 (9.1)

Decrease in accounts and notes payable and other

liabilities (117.1) (17.5)

Increase in deferred revenue 3.6 36.5

Net cash provided by operating activities(A) 65.7 101.4

Unaudited US GAAP results for the three months to March 31, 2008

Consolidated Statements of Cash Flows

3 months to March 31, 2008 2007

$M $M

CASH FLOWS FROM INVESTING ACTIVITIES:

Movements in restricted cash 5.0 (0.4)

Expenses related to acquisition of New River

Pharmaceuticals Inc. - (3.1)

Purchases of long-term investments (1.0) (2.1)

Purchases of property, plant and equipment (27.8) (17.9)

Purchases of intangible assets - (28.2)

Proceeds from disposal of long-term assets 10.3 -

Proceeds from disposal of property, plant and

equipment 0.1 -

Proceeds/deposits received from sale of product

rights 5.0 7.0

Returns from equity investments - 1.2

Net cash used in investing activities(B) (8.4) (43.5)

CASH FLOWS FROM FINANCING ACTIVITIES:

Payment of debt arrangement and issuance costs - (2.9)

Payment under building financing obligation (0.2) -

Proceeds from exercise of options 0.3 22.3

Proceeds from issue of common stock, net - 878.3

Proceeds from exercis
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SOURCE Shire plc
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