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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

(7.6) -

Total operating expenses 539.2 387.0

Operating income 163.0 141.2

Interest income 12.7 19.8

Interest expense (17.3) (7.8)

Other income, net 12.7 0.5

Total other income, net 8.1 12.5

Income before income taxes and equity in earnings of

equity method investees 171.1 153.7

Income taxes (44.1) (41.5)

Equity in earnings of equity method investees, net of

taxes 1.6 0.5

Net income 128.6 112.7

(1) Cost of product sales does not include amortization of intangible assets relating to intellectual property rights acquired, which is included in Depreciation and amortization. Amortization of intangible assets relating to favourable manufacturing contracts is recorded in Cost of product sales.

(2) Costs, predominantly relating to manufacturing set-up costs for new products, of $1.8 million for the three months to March 31, 2007, have been reclassified from Research and development to Cost of product sales.

Unaudited US GAAP results for the three months to March 31, 2008

Consolidated Statements of Operations (continued)

3 months to March 31, 2008 2007

Earnings per ordinary share - basic 23.6c 21.6c

Earnings per ordinary share - diluted 22.7c 21.3c

Earnings per ADS - diluted 68.1c 63.9c

Weighted average number of shares:

Million
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SOURCE Shire plc
Copyright©2008 PR Newswire.
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