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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

$M $M

Shareholders' equity:

Common stock of 5p par value; 750.0 million

shares authorized; and 559.4 million shares

issued and outstanding (2007: 750.0 million

shares authorized; and 556.8 million shares

issued and outstanding)

48.8 48.7

Exchangeable shares: nil shares issued and

outstanding (2007: 0.7 million) - 33.6

Treasury stock (313.9) (280.8)

Additional paid-in capital 2,557.8 2,509.9

Accumulated other comprehensive income 32.4 55.7

Accumulated deficit (1,011.5) (1,140.1)

Total shareholders' equity 1,313.6 1,227.0

Total liabilities and shareholders' equity 4,322.1 4,330.1

Unaudited US GAAP results for the three months to March 31, 2008

Consolidated Statements of Operations

3 months to March 31, 2008 2007

$M $M

Revenues:

Product sales 631.7 461.5

Royalties 65.1 59.5

Other revenues 5.4 7.2

Total revenues 702.2 528.2

Costs and expenses:

Cost of product sales(1) (2) 90.3 65.3

Research and development(2) 119.1 79.0

Selling, general and administrative 293.0 213.8

Depreciation and amortization(1) 44.4 28.9

Gain on sale of product rights
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SOURCE Shire plc
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