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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

interest received on cash and cash equivalents. Interest income for the three months to March 31, 2008 is lower than the same period in 2007 due to lower average cash and cash equivalent balances and lower average US Dollar interest rates.

Interest expense

For the three months to March 31, 2008 the Company incurred interest expense of $17.3 million (2007: $7.8 million). The increase in interest expense compared to the same period in 2007 mainly relates to Shire's US$1,100 million principal amount 2.75% convertible bonds which were issued in May 2007.

In both three month periods to March 31, 2008 and 2007 interest expense includes a provision for interest, which may be awarded by the Court in respect of amounts due to those ex-Transkaryotic Therapies, Inc. ("TKT") shareholders who have requested appraisal of the acquisition consideration payable for their TKT shares. The trial date of May 12, 2008 has been postponed and no new trial date has been set. Further information on this litigation can be found in our filings with the SEC, including our Annual Report on Form 10-K for the year to December 31, 2007.

Other income

Other income includes a gain of $9.4 million arising from the sale of Shire's minority equity investment in Questcor Pharmaceuticals Inc., a specialty pharmaceutical company focused on providing prescription drugs for central nervous system (CNS) disorders. The disposal generated cash consideration of $10.3 million.

Taxation

The effective rate of tax for the three months to March 31, 2008 was 26% (2007: 27%). Excluding the tax effect of items excluded from non GAAP income as outlined on pages 24-25, the effective rate of tax on non GAAP income is 28% (2007: 27%). Shire reaffirms its previous guidance (issued as part of the 2007 year end results) that the full year effective tax rate on non GAAP income is expected to be approximately 23% (2007: 21%).

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SOURCE Shire plc
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