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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

r with growth in new markets in Latin America and Japan. The product is now approved for marketing and commercial distribution in 39 countries.

REPLAGAL - Fabry disease

Sales for the three months to March 31, 2008 were $42.5 million, an increase of 31% compared to the same period in 2007 (2007: $32.5 million). Expressed in transaction currencies (REPLAGAL is primarily sold in Euros and Pounds Sterling) sales increased by 19% primarily due to higher unit sales in Europe and Canada as the Company continues to identify new patients. Exchange rate movements against the US dollar accounted for the remaining 12% increase in sales.

3. Royalties

Royalty revenue increased by 9% to $65.1 million for the three months to March 31, 2008 (2007: $59.5 million). The following table provides an analysis of Shire's royalty income:

Royalty Highlights

Royalties

to Shire Royalty

Growth(1)

Product $M %

3TC 37.3 5%(2)

ZEFFIX 10.4 14%(3)

Other 17.4 17%

Total 65.1 9%

(1) Compared with Q1 2007.

(2) Includes favourable foreign exchange movements of 7%

(3) Includes favourable foreign exchange movements of 13%

3TC - HIV infection and AIDS Shire receives royalties from GSK on worldwide 3TC sales. Royalties from sales of 3TC for the three months to March 31, 2008 were $37.3 million, comparable to the same period in 2007 (2007: $35.5 million). Excluding favourable foreign exchange movements of 7%, there has been a decline of 2% compared to the same period in 2007. While the nucleoside analogue market for HIV has continued to grow, competitive pressures from new products and entrants to the market have
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SOURCE Shire plc
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