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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

red to Q1 2007.

Specialty Pharmaceuticals

ADDERALL XR - ADHD

ADDERALL XR is the leading brand in the US ADHD market. As a result of the launch of VYVANSE in July 2007 ADDERALL XR's average share of the US ADHD market for Q1 2008 fell to 23.7% (2007: 26.3%). US prescriptions for ADDERALL XR for the period to March 31, 2008 decreased by 5% compared to the same period in 2007 due to a 10% decrease in average market share offset by 6% growth in the US ADHD market.

Sales of ADDERALL XR for the three months to March 31, 2008 were $261.5 million, an increase of 5% compared to the same period in 2007 (2007: $249.1 million). Product sales grew despite the decline in US prescriptions primarily due to a price increase in October 2007.

Litigation proceedings concerning Shire's ADDERALL XR patents are ongoing. Further information on this litigation can be found in our filings with the US Securities and Exchange Commission ("SEC"), including our Annual Report on Form 10-K for the year to December 31, 2007.

VYVANSE - ADHD

VYVANSE was launched in the US market in July 2007. For the three months to March 31, 2008 VYVANSE's average market share was 6.1% of the US ADHD market, with prescription demand increasing 36% compared to Q4 2007. Product sales for the three months to March 31, 2008 were $54.4 million (2007: $nil). This compares to sales of $65.9 million in Q4 2007 which included both deferred launch sales and significant wholesaler restocking.

DAYTRANA - ADHD

Product sales for the three months to March 31, 2008 were $20.3 million (2007: $11.9 million). Prescriptions reduced by 5% from last year due to a reduction in DAYTRANA's average share of the US ADHD market from 2.2% in Q1 2007 to 2.0% in 2008 following the launch of VYVANSE.

Despite the decrease in prescriptions compared to 2007, sales of DAYTRANA grew 71% due to lower sales deductions (primarily lower coupon deductions compared to 2007 which were impac
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SOURCE Shire plc
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