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Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance
Date:4/25/2008

2007 (2007: $59 million);

- The effective tax rate on non GAAP income for 2008 is expected to be approximately 23%; and

- Fully diluted share capital (inclusive of options and convertible bonds) is expected to be approximately 590 million shares, with $13 million of convertible bond interest (after tax) expected to be added back to non GAAP net income for the purpose of calculating fully diluted EPS.

For 2008, Shire will report its non GAAP earnings based on net income adjusted for the following items, all of which are excluded from the financial outlook for the full year as stated above:

- Intangible asset amortization charges, which are expected to rise approximately 25% over the 2007 charge of $95 million primarily due to a full year's amortization of the VYVANSE paediatric intangible asset;

- Gains on the sale of non-core assets of $43 million (previous guidance: $29 million);

- Upfront payments and milestones in respect of in-licensed and acquired products, including the payment to Zymenex for METAZYM of $135 million; and

- Costs associated with the introduction of a new holding company.

In contrast to 2007, no adjustment will be made to exclude the FAS123R charge from non GAAP earnings in 2008. The non GAAP earnings for 2007 have therefore been recalculated to include the impact of the share based compensation charge which had previously been excluded.

Dial in details for the live conference call for investors 14:00 BST/09:00 EDT on April 25, 2008:

UK and International dial in: +44-203-023-4496

US dial in: +1-866-966-5335

Password/Conf ID: Shire

Webcast:

http://www.shire.com/shire/InvestorRelations/showevent.jsp?tn=2&m1=33&m 2=&

event=66

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SOURCE Shire plc
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