Navigation Links
Flagship Biosciences Introduces a New Technique for Measuring Fibrosis in Nonalcoholic Steatohepatitis
Date:6/24/2013

Portland, OR (PRWEB) June 24, 2013

Nonalcoholic steatohepatisis or NASH is a common, often "silent" chronic liver disease, occurring in people who drink little or no alcohol. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins.

Fibrosis generally occurs at a low area percentage in tissue, and manual subjective evaluation cannot accurately discern discrete changes at low levels. To address this obstacle, Flagship's quantitative Tissue Image Analysis (tIA) method has been used to determine precise percentages of induced fibrosis in various experimental animal models. Results allowed discrimination of induction and therapy-related reductions in collagen levels at less than 5% increments, and these changes can only be measured accurately with computer-assisted pathology.  Data from tIA can be combined with histomorphologic and molecular data to allow greater utilization of animal tissue in antifibrotic drug development.

This quantitative approach of measuring fibrosis is being applied to different liver fibrosis-inducing models and in different species. This same approach has also been applied to measure fibrosis in cardiac and renal tissues and is being investigated for use in pulmonary fibrosis animal models.

Flagship's approach combines the expert knowledge of experienced scientists with innovations in digital pathology, leading to greater data accuracy and more efficient utilization of resources in drug development.

Flagship develops new tissue analysis endpoints for use in both research and CLIA clinical trials as part of their histology services.

Read the full story at http://www.prweb.com/releases/2013/6/prweb10852679.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Clinovo, Leading CRO in the Bay Area, Endorsed by Medical Device Company for Their Flagship System: Clincapture
2. BioXcel Launches Its Flagship Product, PharmGPS™
3. Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer
4. The Law Firm of Levi & Korsinsky, LLP Launches an Investigation Into Possible Securities Laws Violations by Pacific Biosciences of California, Inc.
5. Coronado Biosciences to Present at the Oppenheimer 22nd Annual Healthcare Conference
6. Coronado Biosciences Announces Phase 1 Results of CNDO-109 in AML to be Presented at the American Society of Hematology
7. Sangamo BioSciences Announces Presentation of New Data from ZFP Therapeutic® Program in Hemophilia B at American Society for Hematology Meeting
8. Sangamo BioSciences Announces Presentation at J.P. Morgan Healthcare Conference
9. Sofie Biosciences Is Awarded a US Patent on a Family of Novel PET Probes for Use in Oncology and Immunology
10. Sangamo BioSciences Announces Fourth Quarter and Full Year 2011 Conference Call and Webcast
11. Neurocrine Biosciences to Present at the 14th Annual BIO CEO & Investor Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... 2017 , ... Franz Inc ., an early innovator ... market leader for Semantic Graph Database technology, today announced Allegro ... effective system for developing and deploying applications to solve the challenges developers face ...
(Date:4/25/2017)... ... April 25, 2017 , ... Dr. Robert G. Schwartz, ... proudly announced today that acclaimed physiatrist Matthew Terzella, MD, has joined the practice ... , Dr. Terzella completed his residency in Physical Medicine and Rehabilitation at UMDNJ-Robert ...
(Date:4/24/2017)... ... April 24, 2017 , ... It ... a cellular milieu; however, the broad application of this cellular target engagement concept ... sensitive quantitative readouts. Cell-based thermal stabilization assays are valuable methods for particular applications, ...
(Date:4/21/2017)... TX (PRWEB) , ... April 21, 2017 , ... Having ... than a year, Formaspace is pleased to introduce it to top lab design architects ... Formaspace CEO Jeff Turk and VP of Industrial Design and Engineering Greg Casey will ...
Breaking Biology Technology:
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
Breaking Biology News(10 mins):