Navigation Links
Flagship Biosciences Introduces a New Technique for Measuring Fibrosis in Nonalcoholic Steatohepatitis
Date:6/24/2013

Portland, OR (PRWEB) June 24, 2013

Nonalcoholic steatohepatisis or NASH is a common, often "silent" chronic liver disease, occurring in people who drink little or no alcohol. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins.

Fibrosis generally occurs at a low area percentage in tissue, and manual subjective evaluation cannot accurately discern discrete changes at low levels. To address this obstacle, Flagship's quantitative Tissue Image Analysis (tIA) method has been used to determine precise percentages of induced fibrosis in various experimental animal models. Results allowed discrimination of induction and therapy-related reductions in collagen levels at less than 5% increments, and these changes can only be measured accurately with computer-assisted pathology.  Data from tIA can be combined with histomorphologic and molecular data to allow greater utilization of animal tissue in antifibrotic drug development.

This quantitative approach of measuring fibrosis is being applied to different liver fibrosis-inducing models and in different species. This same approach has also been applied to measure fibrosis in cardiac and renal tissues and is being investigated for use in pulmonary fibrosis animal models.

Flagship's approach combines the expert knowledge of experienced scientists with innovations in digital pathology, leading to greater data accuracy and more efficient utilization of resources in drug development.

Flagship develops new tissue analysis endpoints for use in both research and CLIA clinical trials as part of their histology services.

Read the full story at http://www.prweb.com/releases/2013/6/prweb10852679.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Clinovo, Leading CRO in the Bay Area, Endorsed by Medical Device Company for Their Flagship System: Clincapture
2. BioXcel Launches Its Flagship Product, PharmGPS™
3. Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer
4. The Law Firm of Levi & Korsinsky, LLP Launches an Investigation Into Possible Securities Laws Violations by Pacific Biosciences of California, Inc.
5. Coronado Biosciences to Present at the Oppenheimer 22nd Annual Healthcare Conference
6. Coronado Biosciences Announces Phase 1 Results of CNDO-109 in AML to be Presented at the American Society of Hematology
7. Sangamo BioSciences Announces Presentation of New Data from ZFP Therapeutic® Program in Hemophilia B at American Society for Hematology Meeting
8. Sangamo BioSciences Announces Presentation at J.P. Morgan Healthcare Conference
9. Sofie Biosciences Is Awarded a US Patent on a Family of Novel PET Probes for Use in Oncology and Immunology
10. Sangamo BioSciences Announces Fourth Quarter and Full Year 2011 Conference Call and Webcast
11. Neurocrine Biosciences to Present at the 14th Annual BIO CEO & Investor Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... ... a four-tiered line of medical marijuana products targeting the needs of consumers who ... packaging of Kindred takes place in Phoenix, Arizona. , As operators of two ...
(Date:10/6/2017)... ... October 06, 2017 , ... The ... and technology sector at their fourth annual Conference where founders, investors, innovative practitioners ... and the ELEVATE pitch competition showcasing early stage digital health and med tech ...
Breaking Biology Technology:
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
Breaking Biology News(10 mins):