Fitting pieces for biosensors (cientists 'stick' the even smaller targe...)

Fitting pieces for biosensors

Date:4/7/2009

cientists 'stick' the even smaller target molecules to make them more manageable.

Many other modifications of the SELEX procedure have been developed by teams in research institutes around the world enabling aptamer selections for a wide range of different applications. In the new book "Aptamers in Bioanalysis" (M. Mascini, Wiley-Interscience) Beate Strehlitz and Regina Stoltenburg describe the SELEX procedure and its many variants in a review chapter.

By use of the FluMag SELEX procedure, developed by the UFZ research group in Leipzig, aptamers for a wide range of target molecules can be selected. Thus it has been used successfully to generate aptamers for a protein, a peptide and for ethanolamine, the smallest molecular aptamer target so far. The ethanolamine-binding aptamers have been patented. Additionally Dr Christine Reinemann succeeded in selecting aptamers for soluble constituents of Penicillium expansum spores (mould spore extract). Based on this aptamers she hopes to develop a detection method for mould fungi within a project with third-party funding from Saxony's Office for Environment, Agriculture and Geology (LfULG). Mould fungi are one of the reasons behind the increase in allergies in Germany. Together with PhD student Sren Linkorn and researchers from the Institute of Food Technology and Bioprocess Engineering at TU Dresden, Dr Regina Stoltenburg wants to select aptamers that can recognise pathogenic bacteria. These aptamers are supposed to develop a biosensor-based detection method for pathogens in water. This research is being conducted within the International Water Research Alliance Saxony (IWAS). A quick method for identifying these harmful germs is particularly important in arid parts of the world because contaminated drinking water in these areas can cause diseases, death and even epidemics.

The German Federal Ministry of Education and Research (BMBF) has just approved a joint project under leadership of Forschungs
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Contact: Tilo Arnhold
presse@ufz.de
49-341-235-1635
Helmholtz Association of German Research Centres
Source:Eurekalert

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Fitting pieces for biosensors(cientists 'stick' the even smaller targe...)