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Fitting a biological nanopore into a man-made one, new ways to analyze DNA
Date:11/29/2010

rmed chiefly by lead author dr. Adam Hall, now demonstrates a simple method to implant the pore-forming proteins into a robust layer in a silicon chip. Essentially, an individual protein is attached to a larger piece of DNA, which is then pulled through a pre-made opening in a silicon nitride membrane (see the attached image). When the DNA molecule threads through the hole, it pulls the pore-forming protein behind it, eventually lodging it in the opening and creating a strong, chip-based system that is tailor-made for arrays and device applications. The researchers have shown that the hybrid device is fully functional and can be used to detect DNA molecules.


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Contact: Cees Dekker
c.dekker@tudelft.nl
Delft University of Technology
Source:Eurekalert

Page: 1 2

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