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First targeted and programmable nanomedicine to show clinical antitumor effects published
Date:4/4/2012

design through medicinal chemistry."

"Previous attempts to develop targeted nanoparticles have not translated into clinical success because of the inherent difficulty of designing and scaling up a particle capable of targeting, long-circulation via immune-response evasion, and controlled drug release," commented Robert Langer, Sc.D., BIND Founder and David H. Koch Institute Professor at MIT. "BIND-014 is the first therapeutic of its kind to reach clinical evaluation and has demonstrated an increases of up to ten fold in drug concentration in tumors, which lead to substantially better efficacy and safety. This represents a major advance in cancer therapy and a significant milestone for science, technology and medicine."

Key findings include:

  • Preclinical data including pharmacokinetic characteristics consistent with prolonged circulation and controlled drug release with plasma concentrations remaining up to at least 100-fold higher than conventional docetaxel for over 24 hours, as well as up to a ten-fold increase in intratumoral drug concentrations with prolonged and enhanced tumor growth suppression in multiple tumor models compared with conventional docetaxel.
  • Initial clinical data in a heavily pretreated patient population with 17 patients with advanced or metastatic solid tumor cancers indicate that BIND-014 displays pharmacological characteristics consistent with preclinical findings of differentiated pharmacokinetics and accumulation at tumor sites with clinical effects seen at doses as low as 20% of the normally prescribed docetaxel dose and in cancers in which docetaxel has minimal activity..
  • BIND-014 has been administered at doses of up to 75 mg/m2 and dose escalation is ongoing. BIND-014 is generally well tolerated with no new toxicities observed to date.

Study coauthors included scientific and clinical advisors from the Massachusetts Institute of Technology (MIT), Harvard Medical School and Dana-Farber Cancer In
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Contact: Kathryn Morris
kathryn@theyatesnetwork.com
914-204-6412
The Yates Network
Source:Eurekalert

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