Navigation Links
First step to new therapy for chronic bowel disease
Date:7/6/2010

Scientists associated with VIB (Flanders Institute for Biotechnology) and Ghent University (UGent) have discovered that A20 protein plays an important protective role in diseases associated with chronic bowel inflammation. This makes A20 into a promising therapeutic target for the development of new anti-inflammatory drugs.

Chronic bowel inflammation

Inflammation is a normal protective reaction against tissue damage and infection. This immune response is very specific and only possible after a whole cascade of signals. Sometimes, however, something goes awry in the chain of reactions, leading to an out-of-control inflammation process and possibly undesirable responses against endogenous substances. Crohn's disease and ulcerative colitis are both chronic inflammatory disorders of the gastrointestinal tract. Hence, reining in the runaway immune system would seem to be the obvious treatment for these diseases. But this requires a thorough knowledge of the whole process.

TNF, NF-κB and A20

The NF-κB protein plays a critical role in the inflammatory response and is activated by e.g. TNF, which is produced by the white blood cells and acts as a kind of messenger molecule between multiple cell types. This leads in the cell to the production of e.g. A20, a protein that shuts down NF-κB activation and is able to prevent cell death.

A20, new therapeutic target

To identify the physiological role of A20 protein, Lars Vereecke and his colleagues, under the leadership of Geert van Loo and Rudi Beyaert, studied mice whose intestinal epithelial cells (cells that line the intestinal wall) were incapable of producing A20 protein. Their experiments showed that the intestinal epithelial cells of these mice were very sensitive to TNF-induced apoptosis, which in turn made them highly susceptible to developing chronic bowel inflammation. When intestinal epithelium breaks down, bacteria have a ch
'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology technology :

1. IIVS Receives First Mark Twain Ethical Science Award for Successes In Replacing Animals for Chemical and Product Safety Testing
2. Sandia Labs reports first monolithic terahertz solid-state transceiver
3. FDA Approves First-of-Its-Kind HIV Test Which Can Detect HIV Days Earlier Than Current U.S. Tests
4. Texas A&M veterinary researchers achieve cloning first
5. First DePuy ASR Hip Replacement Lawsuit Filed in the US
6. Huiheng Medical, Inc. Announces Conference Call to Discuss First Quarter 2010 Results
7. FirstAidWarehouse.co.uk Examines High Blood Pressure, or Hypertension, and Blood Pressure Monitors
8. YM BioSciences enrolls first US patient in Phase II randomized, double-blind brain metastases trial for nimotuzumab
9. Concord Medical Announces First Quarter 2010 Financial Results
10. t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA
11. Launch of GenoCon: First-ever Contest in Rational Genome Design Based on Semantic-web Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of strategic ... business, and media events in the United States ... associate Virginia Cox , JD, is returning to the firm,s ... Cox re-joins 3D after more than two years of service ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... of enzymes routinely used to synthesizing some of nature's most ... new way to expand on nature's chemical creativity to make ... 1) in the journal Science , a team led ... the University of Wisconsin-Madison , describes the discovery of ...
... the new darling of Wall Street. In the past ... private equity firms, venture capital firms, and hedge funds. ... trading multiples in excess of $5 per gallon of ... EBITDA, and 1,000x trailing four quarters of net income. ...
... - When it comes to attracting venture capital, Wisconsin has ... Investors on the East and West coasts have basically stuck ... in the Heartland, with the exception of a few states ... have been signs that a few flights ferrying venture capitalists ...
Cached Biology Technology:UW finds new path to anti-cancer agents 2UW finds new path to anti-cancer agents 3Ethanol producers are at a crossroads 2Ethanol producers are at a crossroads 3Ethanol producers are at a crossroads 4Ethanol producers are at a crossroads 5Ethanol producers are at a crossroads 6That blip on the national venture capital radar screen may be Wisconsin 2That blip on the national venture capital radar screen may be Wisconsin 3
(Date:4/17/2014)... N.M. A credit-card-sized anthrax detection cartridge developed at ... business makes testing safer, easier, faster and cheaper. ... anthrax, is commonly found in soils all over the ... in both humans and animals. The bacteria can survive ... B. anthracis may occur through skin contact, ...
(Date:4/17/2014)... in German . ... they also provide us with a continuous stream of information ... or sit still in a car the world glides ... retinas. Seemingly without effort, our brain calculates self-motion from this ... and a steady gaze during our own movements. Together with ...
(Date:4/17/2014)... hydrogen sulfide in order to properly multiply and form ... Center for Craniofacial Molecular Biology at the Herman Ostrow ... principal investigator on the project, said the presence of ... of calcium ions. The essential ions activate a chain ... creation of new bone tissue, and keeps the breakdown ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4
... it may sound like an oxymoron, a University of Iowa ... skull from a "pygmy-sized" giant panda -- the earliest-known ancestor ... some two million years ago. , The ancestor of today's ... Ciochon, UI professor of anthropology. Ciochon (pronounced schuh-HON) is a ...
... the link between the way an animal moves and the dimensions ... semicircular canals of the inner ear on each side of the ... on 26 June in the print edition of the Proceedings of ... edition during the week of 18 to 22 June. , ...
... cells that is altered by genetic mutations recently identified in ... mutations affect cellular function and could provide a target for ... a team of Emory University scientists will be published June ... journal. , Parkinson disease is a degenerative disorder ...
Cached Biology News:UI anthropologist, colleagues discover remains of earliest giant panda 2Reconstructing the biology of extinct species: A new approach 2Researchers identify protein pathway involved in Parkinson disease development 2
Anti-TWIK-1 Immunogen: Purified peptide from amino acids 53-69 of human TWIK-1 (Accession number O00180)....
Monoclonal 8C2.1 is specific for Bunyavirus G1 as tested by neutralization, immunoprecipitation and immunobinding assays....
BI-1 Polyclonal Antibody Storage Temperature: -20C Shipping: gel pack Shelf-Life: 12 months...
...
Biology Products: