Navigation Links
First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU
Date:3/18/2011

sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe into tyrosine. KUVAN is to be used in conjunction with a Phe-restricted diet. KUVAN has received orphan drug designation from both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMEA).

About PKUPhenylketonuria (PKU), a genetic metabolic disorder affecting approximately 50,000 diagnosed patients in the developed world, is caused by a deficiency of the enzyme phenylalanine hydroxylase (PAH). PAH is required for the metabolism / breakdown of phenylalanine (Phe), an essential amino acid found in most protein-containing foods. If the active enzyme PAH is not present in sufficient quantities, Phe accumulates to abnormally high levels in the blood and tissues, and becomes toxic to the brain. The consequences of sustained high blood Phe levels may result in a variety of serious neurological complications including severe mental retardation and brain damage, mental illness, seizures, tremors, behavioral problems and limited cognitive ability. Blood Phe levels may be managed by adhering to a life-long Phe-restricted diet regimen. However, some patients may not respond to diet alone and for many, maintaining a Phe-restricted diet is extremely challenging, especially during adolescence and adulthood. As a result, blood Phe levels in many PKU patients remain high, which may cause problems with neurocognitive functioning. Because of newborn screening efforts implemented in the 1960s and early 1970s, virtually all PKU patients under the age of 40 in developed countries have been diagnosed at birth. To learn more about PKU, please visit www.PKU.com.

About BioMarinBioMarin develops and commercializes innovative biopharmaceuticals for serious diseases and medical conditions. The company's product
'/>"/>

SOURCE BioMarin Pharmaceutical Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related biology technology :

1. FDA Approves First-of-Its-Kind HIV Test Which Can Detect HIV Days Earlier Than Current U.S. Tests
2. InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625
3. RAND study finds increase in piracy and terrorism at sea
4. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist
5. Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure
6. Logical Therapeutics Inc. Announces Results of Phase 1b Clinical Study of its Naproxen Prodrug
7. Video: CSL Behring Provides $1.2M Grant for Worlds First Study of Postpartum Women with VWD, Common Bleeding Disorder
8. RainDance and Scripps to Collaborate on Targeted Sequencing for Wellderly Study
9. Preliminary Report of American Biotech Labs HIV Study Featured in Inaugural Issue of Journal of the Science of Healing Outcomes
10. Pharmasset Reports Preliminary Results of a 4-week Proof-of-Concept Combination Study of R7128 for the Treatment of Chronic Hepatitis C in Genotype 2 or 3 Non-Responders
11. ESBATech Announces Successful Completion of Phase I Clinical Study for Lead Antibody Fragment in Ophthalmic Indications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... Maryland Heights, MO (PRWEB) , ... August 26, ... ... is announcing it is increasing its investment in the development and manufacture of ... increase demand. The company’s scientific team's extensive expertise with protein chemistry has ...
(Date:8/26/2015)... , August 26, 2015 Israel Proves ... DiaCardio wins 1 st place  Wayerz comes in ... Israel by venture capital fund JVP, with ... the US, China , Israel ... .  Impressive achievement for the Israeli representatives in ...
(Date:8/26/2015)... ... ... PRC Clinical, a Clinical Trial Management Expert CRO, will be ... California. The Clinical Trial Management Expert CRO seeks to introduce more California-based sponsors to ... , Stem Cell Meeting on the Mesa on October 7-9 in ...
(Date:8/25/2015)... ... 2015 , ... Vets Plus, Inc. recently installed a new ... added a AS16 Sharples centrifuge to harvest products after fermentation. The addition of ... process development. , The new centrifuge greatly expands production capabilities for Vets ...
Breaking Biology Technology:Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3New centrifuge and fermentor expand product development capacity at Vets Plus 2
... July 2 Pearl Therapeutics, Inc.,a biopharmaceutical company ... it has completed the closing of an $18,million ... an extension to,its first venture financing, which closed ... Pearl,s existing investors Clarus Ventures, New Leaf,Ventures, 5AM ...
... Research conducted at The,Walter and Eliza ... a,major licensing agreement signed between Australian biotechnology ... Under the Development and Licensing Agreement, ... for multiple sclerosis (MS) and other autoimmune,conditions. ...
... July 2 /Xinhua-PRNewswire/ -- WuXi PharmaTech (NYSE:,WX), a ... outsourcing company with operations in China and the ... Bob Zhu as Vice President,of Human Resources., ... joining WuXi PharmaTech, Mr. Zhu worked as Head ...
Cached Biology Technology:Pearl Therapeutics Closes $18 Million Financing Round Led By Committed Investors 2MS Drug Development Agreement Based on WEHI's Medicinal Chemistry 2WuXi PharmaTech (NYSE: WX) Appoints Mr. Bob Zhu as VP of HR 2
(Date:8/18/2015)... , Aug. 17, 2015 Research and ... of the "Global Biometric Authentication & Identification ... Estimation & Forecast, 2015-2020" report to their ... and identification systems market is expected to grow ... to 2020 and generate over $25 billion (approximately) ...
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that four of its ... solution, have officially been named FIDO Certified™ by ... of the certification, Synaptics, Natural ID™ fingerprint solutions ... Authentication Framework (UAF) standard and are interoperable among ...
(Date:8/6/2015)... Germany , August 6, 2015 ... (SMI) shows the world,s first Eye Tracking ... Epson,s Moverio BT-200 see-through head mounted display and on ... unprecedented quality and efficiency is brought to personalized visualization ... the first time, professionals and researchers can integrate gaze, ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... northeastern United States are more likely to develop rheumatoid ... and vitamin D deficiency, says a new study led ... In the paper, which appears online in the ... led by Dr. Vernica Vieira, MS, DSc, associate professor ...
... insect-feeding birds, bats and lizards to the front lines ... the results of more than 100 experiments conducted on ... colleagues found that these insect-gobbling animals increase plant growth ... damage they do to the plant life that helps ...
... Life Sciences Discovery Fund (LSDF) today announced nearly $15 ... initiatives spearheaded by three Washington state life sciences organizations. ... enhance the diagnosis and treatment of cancer and other ... of Sage Bionetworks, will use powerful computational tools to ...
Cached Biology News:BUSPH study links rheumatoid arthritis to vitamin D deficiency 2Washington State Life Sciences Discovery Fund awards health research program grants 2
E2F2 protein...
Anti-DDDDK-Tag (Enterokinase Cleavage Site), Agarose Conjugate Research Focus: tag Storage: 4C Shipping Temperature: 4C...
Goat polyclonal to XAGE1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGFGFRRQGEDNT, corresponding to C terminal amino acids 149-160 of Human XAGE1 Entrez Gene ID: 9...
Sheep polyclonal to Staphylococcus DNase ( Abpromise for all tested applications). Antigen: Full length native protein (purified)....
Biology Products: