Navigation Links
First genetically engineered malaria vaccine to enter human trials
Date:7/29/2009

d Army Institute for Research and the University of Maryland, had used knowledge from several decades ago when scientists proved that irradiated malaria parasites provide protection against subsequent malaria infection in animal models and humans in developing the vaccine.

"Although vaccines are under development that use whole malaria parasites weakened by irradiation to protect against infection, their safety and effectiveness rely on a precise irradiation dose and trial results have been variable," Professor Cowman said. "We believe that our genetically attenuated parasite approach provides a safe and reproducible way of developing a whole organism malaria vaccine."

Professor Cowman said it was unlikely the weakened parasites used in the vaccine would regain their potency as the genes had been deleted from the genome and could not be recreated by the parasite. "In addition, the 'one-two punch' approach of deleting two essential genes make it extremely unlikely that the attenuated parasite vaccine could restore its capacity to multiply and lead to disease," he said.

The human trials of the vaccine will take place at the Walter Reed Army Institute of Research in Maryland, US. The genetically attenuated parasites to be used in the trial are being manufactured at the Walter and Eliza Hall Institute, which has the only facility worldwide capable of producing genetically-altered malaria parasites that comply with the good manufacturing practice guidelines required for human clinical trials.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. First U.K. Stem Cell Awareness Rally to Take Place in Manchester, England on August 9th, 2009
2. RadMD First to Offer CME-Certified Education and Training For Medical Imaging in Clinical Trials
3. GreenHouse Debuts the World's First E-Fuel MicroFuelerTM in Los Angeles
4. FDA Grants First Authorization of a Commercial 2009 H1N1 Flu Test for use During Pandemic Flu Emergency to Quest Diagnostics Focus Diagnostics Business
5. Surgeon Performs First Single Incision Peri-Umbilical Laparoscopic Surgery in the State of Missouri
6. OpenQ Posts a 200% Revenue Growth in the First Half of 2009
7. Essilor : First Half 2009 Revenue
8. Sumavel(TM) DosePro(TM) (sumatriptan injection) Approved by FDA for Acute Migraine and Cluster Headache: First Product Featuring Novel DosePro Needle-Free Delivery System
9. China Biologic Products Hosts its First Forum for Strategy and Development
10. First Catalog Cancer Biochip for Sequence Capture Now Available from febit
11. Microbix Files First Patent Applications On Novel Technology Platform For Large Semen Sexing Market
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First genetically engineered malaria vaccine to enter human trials
(Date:8/21/2014)... 2014 Gallus BioPharmaceuticals , ... and manufacturing organization (CMO) announced today that it ... oncology company focused on the development of innovative ... the anti-prostate specific membrane antigen (PSMA) monoclonal antibody ... Under the agreement the antibody will be produced ...
(Date:8/20/2014)... patented university inventions licensed to biotechnology firms has ... To open these roadblocks, the researchers suggest that ... discovery stage could lead to faster commercialization down ... from discoveries made in university laboratories and licensed ... clinical trials, which have a high failure rate. ...
(Date:8/20/2014)... California (PRWEB) August 20, 2014 ... develop and apply the most complete climate and ... and demanding climate change issues. , Eight national ... forces with the National Center for Atmospheric Research, ... the new effort. Other participating national laboratories include ...
(Date:8/20/2014)... 20, 2014 Not long ago, it ... should be performed late in the development cycle – ... current regulatory trends suggest that, like many things GxP, ... In recent years, multiple drug sponsors have been required ... specific questions during phase I/II. It’s not only clinical ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2
... and beyond have been given a new Web-based tool ... interns among the graduates and students of Wisconsins universities ... brings together the career services offices at the University ... resources of the other four-year campuses of the UW ...
... , a health care software and services company, announced ... version 2.5. The updated product includes integration with FUSION ... billing workflow to run from a single, unified end-user ... create productivity improvements for the radiologist and technologist by ...
... days, Al Jacobs taught students about the power of doubling by talking ... and the pads doubled in area every day: How long would it ... cover a pond of 250,000 square feet? , ,Only 17 days, thanks ... 32 and so on, until on the 17th day, 131,072 square feet ...
Cached Biology Technology:New Web site makes recruiting from Wisconsin universities easier 2Merge eFilm announces release of FUSION RIS version 2.5 2Doubling the lily pads: Controlling the explosion in health care costs 2Doubling the lily pads: Controlling the explosion in health care costs 3
(Date:8/21/2014)... growing in near darkness use a previously unknown process ... research team led by a Penn State University scientist ... research aimed at improving plant growth, harvesting energy from ... occurring on Lake Erie and other lakes worldwide. A ... Science Express edition of the journal ...
(Date:8/21/2014)... eczema and other itchy, flaky maladies in humans has ... coral reefs and the extreme environments of arctic soils ... scientific journal PLOS Pathogens considers the diversity, ... Malassezia in light of new insights gained ... , University of Hawai,i at Mānoa scientist Anthony Amend ...
(Date:8/21/2014)... landmark study aimed at improving the food intake, health ... care homes is among three projects at the University ... from the Canadian Institutes of Health Research (CIHR). ... Health Sciences at Waterloo, and a Schlegel research chair ... years to investigate why many Canadians living in long-term ...
Breaking Biology News(10 mins):Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Grants will fund landmark aging research at Waterloo 2
... Using a carbon nanotube instead of traditional silicon, Cornell ... that hopefully will lead to much more efficient ways of ... on rooftops. The researchers fabricated, tested and measured a ... carbon nanotube. Reported online Sept. 11 in the journal ...
... of Texas at San Antonio (UTSA) has received a ... (NSF) to study nanomaterials and their biomedical applications. ... Education in Materials grant, is the second major NSF ... announced the receipt of $5 million to establish a ...
... diabetes, not only do waistlines matter to women, but so does ... a team of Swedish researchers was just published online in the ... of normal weight develop type 2 diabetes, despite not having any ... fat cells and the development of type 2 diabetes may give ...
Cached Biology News:Carbon nanotubes could make efficient solar cells 2UTSA Physics Department receives $2.7 million to study nanomaterials 2Size of fat cells and waist size predict type 2 diabetes in women 2
... Life Sciences provides cost effective cell culture ... or monoclonal antibodies. Quality at a reasonable ... you require research or commercial product, we ... methods such as roller bottles, hollow fiber, ...
... for hunting and analyzing the rare ... EST sequencing projects, microarrays, functional screenings ... well suited for the normalization of ... though, is specially developed for normalization ...
... Application: The Panorama Mouse/Rat Tissue Extract Protein ... expression in various tissue extracts. The expression ... detected using a protein specific antibody. When ... is visualized by a sensitive chemiluminescent or ...
... StabilGuard Choice Microsphere/Microarray Stabilizer is a ... Plus Stabilizer. This product is an ... a PBS buffer (phosphate buffered saline), pH ... a combination of 0.02% methylisothiazolone and 0.02% ...
Biology Products: