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First detailed timeline established for brain's descent into Alzheimer's
Date:7/11/2012

before symptoms.
  • Decreases in the brain's use of the sugar glucose and slight impairments in a specific type of memory are detectable 10 years before symptoms.

    Researchers also tested participants from DIAN families who do not have any of the mutations that cause inherited Alzheimer's.

    "Family members without the Alzheimer's mutations have no detected change in the markers we tested," Bateman says. "It's striking how normal the Alzheimer's markers are in family members without a mutation."

    Bateman is leading the development of Alzheimer's prevention and treatment trials in DIAN participants. He and his colleagues hope to launch trials later this year.

    DIAN researchers now offer an expanded registry for families with inherited Alzheimer's mutations. They encourage anyone with a family history of multiple generations of Alzheimer's diagnosed before age 55 to visit http://www.DIANXR.org/, where they can register for follow-up contact from researchers to determine whether their family is eligible for participation in DIAN studies.


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    • Contact: Michael C. Purdy
    purdym@wustl.edu
    314-286-0122
    Washington University School of Medicine
    Source:Eurekalert

    0

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