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First Taxane-Based Non-Anthracycline Containing Chemotherapy in Combination With Herceptin (TCH) for HER2 Positive Early Breast Cancer Patients Obtains Approval From the FDA
Date:5/29/2008

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The most common adverse event was grade 3-4 febrile neutropenia (AC-T: 9.1%, AC-TH: 11.0%, TCH: 9.8%). Other common grade 3-4 adverse events included diarrhea (3.0% in the AC-T arm, 5.1% in the AC-TH arm, and 4.9% in the TCH arm) and infection without neutropenia (7.0% in the AC-T arm, 5.5% in the AC-TH arm, and 3.6% in the TCH arm).

The 3 year cumulative incidence of symptomatic cardiac events and congestive heart failure (0.3%, 1.9%, and 0.4% for AC-T, AC-TH, and TCH, respectively) was lower in the TCH arm compared to the AC-TH arm.

About the Cancer International Research Group (CIRG) and Translational Research in Oncology (TRIO)

CIRG is a not-for-profit research organization with offices based in Paris, France and Alberta, Canada. With an international network of 2000 investigators and 450 cancer centers in over 45 different countries, CIRG has conducted a number of new and innovative global studies evaluating systemic therapy for cancer. Recently, CIRG has partnered with the UCLA-based investigator network of Translational Oncology Research International, to form TRIO (Translational Research in Oncology). In addition to a network of dedicated investigators and clinical trial services, TRIO also includes the Slamon/TRIO laboratories at UCLA. Slamon and fellow scientists have developed and adapted preclinical models which allow for the validation of molecular markers, the preclinical assessment of new biologic agents and the characterization of an agent's mechanisms of action. This preclinical work, in turn, generates the clinical hypotheses for the group's future cancer trials in patients. This translational approach was the one used in the BCIRG 006.

TRIO is dedicated to advancing translational cancer research by bringing innovative and targeted therapeutics to clinical practice.

Additional information is available on the Internet at http://www.trioncology.org


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SOURCE Cancer International Research Group
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