Navigation Links
First Taxane-Based Non-Anthracycline Containing Chemotherapy in Combination With Herceptin (TCH) for HER2 Positive Early Breast Cancer Patients Obtains Approval From the FDA

(HR=0.58, 95% CI [0.40-0.83], p=0.0024) compared to the AC-T control arm. There was no statistically significant difference in OS between the two experimental arms (TCH and AC-TH).

Moreover, with the TCH regimen, the risk of congestive heart failure was five-fold lower compared to that observed with AC-TH (0.4% vs 1.9% vs 0.3% in women treated with TCH, AC-TH, and AC-T respectively).

"The BCIRG 006 trial results give us a new option for the treatment of HER2 positive breast cancer. This approach exploits the most recent molecular information regarding the HER2 alteration allowing us to retain the remarkable benefits of Herceptin while leaving behind almost all of the major side effects," said Professor Dennis Slamon, Professor and Chief Hematology-Oncology UCLA Los Angeles and CIRG Chair. "The BCIRG design, while initially received controversially, was based on clean preclinical evidence that led us to test a novel combination of drugs in breast cancer."

About BCIRG 006

The BCIRG 006 was a phase III multicenter study conducted by the CIRG and sponsored by sanofi-aventis (Paris, France) with additional support from Genentech (South San Francisco, USA).

Study design

3,222 women with HER2-positive node-positive and high-risk node-negative operable breast cancer were enrolled and randomly assigned to one of the following treatments:

- AC-T (n=1,073), the anthracycline-containing control regimen consisting

of doxorubicin (A, 60 mg/m2) plus cyclophosphamide (C, 600 mg/m2) every

three weeks for four cycles followed by Taxotere(R) (T, 100 mg/m2)

every three weeks for four cycles.

- AC-TH (n=1.074), the anthracycline-containing experimental regimen

consisting of AC every three weeks for four cycles followed by

Taxotere(R) (T, 100 mg/m2) every three weeks for four cycles plus

Herceptin(R) (H, 4 mg/kg loading dose followed by 2 mg/kg per week

concurrently with

SOURCE Cancer International Research Group
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis
2. GlaxoSmithKline Recognizes University of Michigans Dr. Daniel F. Hayes as the First Recipient of the Gianni Bonadonna Breast Cancer Award
3. Kewaunee Scientific Announces First Quarter Results and Quarterly Dividend
4. Genmab Announces 2007 First Half Year Results
5. Pharsight Achieves First License Sale for Public-Source Database
6. Novare Announces First Ever Single Port Laparoscopic Kidney Removal (Nephrectomy) Using RealHand(TM) HD Instruments
7. ExonHit Therapeutics: Allergan and ExonHits First Collaboration Compound to Begin Human Clinical Trials
8. China Medical Technologies Reports First Quarter Financial Results
9. Pressure BioSciences, Inc. Issued First Patent in Canada
10. Peregrine Pharmaceuticals to Announce First Quarter FY 2008 Financial Results
11. Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer
Post Your Comments:
(Date:7/28/2014)... 28, 2014  InterMune, Inc. (NASDAQ: ITMN ... quarter 2014 financial results at the close of the ... call and webcast will be hosted by InterMune at ... Interested investors and others may participate in the conference ... conference ID#21728775. A replay of the webcast and teleconference will ...
(Date:7/28/2014)... 2014 The National Model Aviation Museum, ... is pleased to announce that it has been granted ... the United States Air Force. , The certification is ... concluded this spring with an on-site inspection by Sarah ... , The National Museum of the United States ...
(Date:7/25/2014)... THOUSAND OAKS, Calif. , July 25, 2014 /PRNewswire/ ... its Board of Directors today declared a $0.61 per ... dividend will be paid on Sept. 5, 2014, to ... business on Aug. 14, 2014.  About ... biology for patients suffering from serious illnesses by discovering, ...
(Date:7/25/2014)... , July 25, 2014 Research ... "Global Metabolomics Market 2014-2018" report to ... Metabolomics or Metabonomics is the ... has become a new experimental technique that is ... environmental sciences. Metabolites are small molecules that are ...
Breaking Biology Technology:InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... SAN DIEGO, Jan. 4, 2012  Halozyme Therapeutics, Inc. (NASDAQ: ... Morgan Healthcare Conference in San Francisco on Wednesday, January ... ET . Greg I. Frost, Ph.D., president and ... corporate overview. (Logo: ) ...
... a leader in personal genetics, has released its second ... most interesting and significant genetic findings in 2011, as ... of genetics in personal health and human development. ... "The genetics revolution is well underway and 2011 had ...
... of thought leaders in Alzheimer,s disease says the science ... widespread use of biomarkers in Alzheimer disease (AD) clinical ... for this incurable disorder. Recommendations by the Alzheimer,s Disease ... for Aging Research in cooperation with the Food and ...
Cached Biology Technology:23andMe Presents Top Ten Most Interesting Genetic Findings of 2011 223andMe Presents Top Ten Most Interesting Genetic Findings of 2011 323andMe Presents Top Ten Most Interesting Genetic Findings of 2011 423andMe Presents Top Ten Most Interesting Genetic Findings of 2011 523andMe Presents Top Ten Most Interesting Genetic Findings of 2011 623andMe Presents Top Ten Most Interesting Genetic Findings of 2011 7Use Biomarkers in Alzheimer's Disease Clinical Trials, Says Expert Group 2Use Biomarkers in Alzheimer's Disease Clinical Trials, Says Expert Group 3
(Date:7/25/2014)... raging this summer and some of the smoke from those ... image collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... smoke has descended over the Great Lakes region of the ... image from July 23, 2014 (first image feature highlighted below) ... off southeastward. In the image, it is over Manitoba ...
(Date:7/25/2014)... from 25 countries and 35 states will attend ... Genetics Society of America (GSA) next week at ... will feature close to 500 presentations (including 70 ... gene expression and regulation, functional genomics, chemical biology ... a variety of diseases. , Of special ...
(Date:7/25/2014)... at the University of Adelaide has opened the way for ... powdery mildew. , In Australia, annual barley production is second ... mildew is one of the most important diseases of barley. ... discovered the composition of special growths on the cell walls ... into the leaf. , The research, by the ARC Centre ...
Breaking Biology News(10 mins):Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2New hope for powdery mildew resistant barley 2
... snakes, tumour cells shed their skin. Cancer is not ... accumulates changes to evade natural defences adapting to new ... neighbouring organs, eventually causing metastasis. Until now little ... processes in a tumour. There is a particularly intriguing ...
... Yale University researchers have identified a key genetic gear ... that could have broad implications for global agriculture. The ... Molecular Cell. "Farmers are limited by the ... controls basic functions such as photosynthesis and flowering, we might ...
... detective work by an international group of researchers may have ... tree-killing fungus that has hit six of the world,s seven ... 1) in the peer-reviewed journal Phytopathology , California emerged ... is the cause of cypress canker disease. It was ...
Cached Biology News:Why cancer cells change their appearance? 2Tree-killing pathogen traced back to California 2Tree-killing pathogen traced back to California 3Tree-killing pathogen traced back to California 4Tree-killing pathogen traced back to California 5
The Varian 4000 GC/MS system offers three easily switchable ionization configurations: internal ionization (II), external ionization (EI) or hybrid chemical ionization (CI)...
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
One-step, microplate or cuvet, colorimetric, detection range 0.04% to 4%. Procedure: 30 min....
... to Presenilin 2 Alzheimer's disease (AD) ... disease carry mutations in the presenilin proteins ... (APP). These disease-linked mutations result in increased ... (main component of amyloid deposits found in ...
Biology Products: