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First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs
Date:10/23/2007

drugs to show activity in these tumor types.

While initially effective in treating cancer, many tumors ultimately develop resistance to standard platinum agents. Prior attempts at developing tri-nuclear platinum containing drug candidates proved disappointing when tested in human clinical trials due to extensive protein binding and de-platination in the bloodstream. These novel second-generation bis-platinate compounds utilize butyrate or carboxylate moieties to improve their pharmacokinetic and pharmacodynamic profiles overcoming the limitations of prior multinuclear based compounds. They were developed to be stable in human plasma while circumventing standard palatinate resistance by causing bi-functional long range inter-strand and intra-strand DNA cross links.

About Platinum Anticancer Agents

Platinum agents are the most broadly used cytotoxic drugs used in the war on cancer. They are part of first-line therapeutic regimens for many common cancers including non-small cell lung, ovarian, colorectal, and testicular cancers. Three important monoplatinates are in common use including, carboplatin for lung and ovarian cancers, oxaliplatin for colorectal cancer, and cisplatin for testicular, lung and ovarian cancers. Global sales of platinum based drugs exceeded $1.5 Billion in 2006.

About Cell Therapeutics, Inc.

Headquartered in Seattle, CTI is a biopharmaceutical company committed to developing an integrated portfolio of oncology products aimed at making cancer more treatable. For additional information, please visit http://www.cticseattle.com.

This press release includes forward-looking statements that involve a number of risks and uncertainties, the outcome of which could materially and/or adversely affect actual future results. Specifically, the risks and uncertainties that could affect the development of our bis-platinate drug candidates, CT-47613 and CT-47609, include ri
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SOURCE Cell Therapeutics, Inc.
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