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First Duplex Test for Parvovirus B19 and Hepatitis A Virus Increases Safety of Human Plasma and Plasma Products
Date:10/4/2010

PLEASANTON, Calif., Oct. 4 /PRNewswire/ -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the cobas® TaqScreen DPX Test for use on the cobas s 201 system is now available with the CE Mark. It is the first IVD test to offer complete coverage of all human genotypes of parvovirus B19 (B19V) and hepatitis A virus (HAV) in one assay. The test is a state-of-the-art, in-vitro nucleic acid amplification technology (NAT) test which simultaneously quantifies B19V genotypes 1, 2 and 3 DNA and detects HAV genotypes I, II and III RNA in individual samples or pooled plasma samples of human origin.

The cobas® TaqScreen DPX Test uses multi-dye, real-time polymerase chain reaction (PCR) technology which allows for the simultaneous detection and identification of individual viral targets without the use of complementary discriminatory tests. The introduction of the cobas® TaqScreen DPX Test makes the cobas s 201 system the first commercially available NAT system for screening blood and plasma for six viruses.

"Roche is committed to providing the broadest coverage and most efficient screening tests to ensure the highest safety of blood and plasma products," said Paul Brown, Ph.D., President and CEO of Roche Molecular Diagnostics. "This new test is one more step toward that goal and complements our current cobas® TaqScreen tests for the detection of HIV, HCV, HBV and WNV."

The cobas® TaqScreen DPX Test can help manage the B19V burden in plasma pools and identify HAV-contaminated units. It allows plasma manufacturers to increase processing efficiency and may reduce the number of units that are discarded. The highly precise, quantitative values obtained for B19V DNA and the test's high sensitivity for HAV RNA meet current regulatory requirements for plasma intended for further manufacture.

Human plasma is fractionated into its components, such as immunoglobulins, albumin, and
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