Navigation Links
Findings could be used to engineer organs
Date:10/25/2012

Biologists have teamed up with mechanical engineers from the University of Texas at Dallas in cell research that provides information that may one day be used to engineer organs.

The research, published online in the Proceedings of the National Academy of Sciences, sheds light into the mechanics of cell, tissue and organ formation. The research revealed basic mechanisms about how a group of bacterial cells can form large three-dimensional structures.

"If you want to create an organism, the geometry of how a group of cells self-organizes is crucial," said Dr. Hongbing Lu, professor of mechanical engineering and holder of the Louis Beecherl Jr. Chair at UT Dallas and an author of the study. "We found that cell death leads to wrinkles, and the stiffer the cell the fewer wrinkles."

Organ formation is the result of individual cells teaming with others. The aggregate of the cells and their environment form a thin layer of what is known as a biofilm. These biofilms form 3-D wrinkled patterns.

Senior author Dr. Grol Sel, now at the University of California, San Diego, and his colleagues noticed dead cells under the wrinkle pattern. They teamed with Lu to discover what came first the cells' death or wrinkling. Lu is an expert in nanomechanics measuring forces on small objects.

They found that groups of cells dying together within the biofilm resulted in the formation of wrinkles. They also found that the stiffness of the biofilm affected the formation of wrinkles. This is significant because it lays the foundation for the first theory about building a structure in tissues and organs taking both the biological and mechanical forces into consideration.

"There are ways to control whether a biofilm is soft or stiff, and then you control the wrinkling and the ultimate structure the cells become," Lu said.

Researchers then controlled the location where cells died and were thereby able to create artificial wrinkle patterns, verifying their findings.

All of the research was done on bacteria known as Bacillus subtilis.

"Bacillus subtilis has many aspects that are similar to other cells," Lu said. "If we understand how this process works in bacteria, it can open up the door to higher levels of life."

The next step, Lu said, is to create more organized 3D structures using higher forms of life.


'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@UTDallas.edu
972-883-4183
University of Texas at Dallas
Source:Eurekalert

Related biology technology :

1. Published Findings In Human Gene Therapy Methods Journal Demonstrate Cardiums New Catheter-Based Method Significantly Boosts Gene Delivery To The Heart
2. New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients
3. Profil Institute Continues to Publish New Findings in Metabolic Research
4. Expanded Findings for FirstMarks Completed Clinical Study for Predicting Near-Term (2-3 Years) MI
5. GeoVax Labs Presents New Findings on Potential HIV Vaccine at 2012 Conference on Retroviruses and Opportunistic Infections (CROI)
6. Live Press Briefing on Findings of Biomedical Industry CEO Survey
7. 23andMe Presents Top Ten Most Interesting Genetic Findings of 2011
8. US Oncology Research Affiliated Physician to Present Findings From Innovative Clinical Trial at 2011 CTRC-AACR San Antonio Breast Cancer Symposium
9. New design could improve condenser performance
10. Needle beam could eliminate signal loss in on-chip optics
11. Protein that helps tumor blood vessels mature could make cancer drugs more effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... CA (PRWEB) , ... June 27, 2016 , ... ... for clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT ... care circle with the physician and clinical trial team. , Using the CONSULT module, ...
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
Breaking Biology Technology:
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):