Navigation Links
Findings could be used to engineer organs
Date:10/25/2012

Biologists have teamed up with mechanical engineers from the University of Texas at Dallas in cell research that provides information that may one day be used to engineer organs.

The research, published online in the Proceedings of the National Academy of Sciences, sheds light into the mechanics of cell, tissue and organ formation. The research revealed basic mechanisms about how a group of bacterial cells can form large three-dimensional structures.

"If you want to create an organism, the geometry of how a group of cells self-organizes is crucial," said Dr. Hongbing Lu, professor of mechanical engineering and holder of the Louis Beecherl Jr. Chair at UT Dallas and an author of the study. "We found that cell death leads to wrinkles, and the stiffer the cell the fewer wrinkles."

Organ formation is the result of individual cells teaming with others. The aggregate of the cells and their environment form a thin layer of what is known as a biofilm. These biofilms form 3-D wrinkled patterns.

Senior author Dr. Grol Sel, now at the University of California, San Diego, and his colleagues noticed dead cells under the wrinkle pattern. They teamed with Lu to discover what came first the cells' death or wrinkling. Lu is an expert in nanomechanics measuring forces on small objects.

They found that groups of cells dying together within the biofilm resulted in the formation of wrinkles. They also found that the stiffness of the biofilm affected the formation of wrinkles. This is significant because it lays the foundation for the first theory about building a structure in tissues and organs taking both the biological and mechanical forces into consideration.

"There are ways to control whether a biofilm is soft or stiff, and then you control the wrinkling and the ultimate structure the cells become," Lu said.

Researchers then controlled the location where cells died and were thereby able to create artificial wrinkle patterns, verifying their findings.

All of the research was done on bacteria known as Bacillus subtilis.

"Bacillus subtilis has many aspects that are similar to other cells," Lu said. "If we understand how this process works in bacteria, it can open up the door to higher levels of life."

The next step, Lu said, is to create more organized 3D structures using higher forms of life.


'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@UTDallas.edu
972-883-4183
University of Texas at Dallas
Source:Eurekalert

Related biology technology :

1. Published Findings In Human Gene Therapy Methods Journal Demonstrate Cardiums New Catheter-Based Method Significantly Boosts Gene Delivery To The Heart
2. New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients
3. Profil Institute Continues to Publish New Findings in Metabolic Research
4. Expanded Findings for FirstMarks Completed Clinical Study for Predicting Near-Term (2-3 Years) MI
5. GeoVax Labs Presents New Findings on Potential HIV Vaccine at 2012 Conference on Retroviruses and Opportunistic Infections (CROI)
6. Live Press Briefing on Findings of Biomedical Industry CEO Survey
7. 23andMe Presents Top Ten Most Interesting Genetic Findings of 2011
8. US Oncology Research Affiliated Physician to Present Findings From Innovative Clinical Trial at 2011 CTRC-AACR San Antonio Breast Cancer Symposium
9. New design could improve condenser performance
10. Needle beam could eliminate signal loss in on-chip optics
11. Protein that helps tumor blood vessels mature could make cancer drugs more effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Diego, CA (PRWEB) , ... June 27, 2016 , ... ... solutions for clinical trials, announced today the Clinical Reach Virtual Patient Encounter ... their care circle with the physician and clinical trial team. , Using the CONSULT ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
Breaking Biology Technology:
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):