Navigation Links
Finding blood clots before they wreak havoc
Date:10/19/2013

ot detect its initial formation.

Bhatia and her colleagues developed their new test based on a technology they first reported last year for early detection of colorectal cancer. "We realized the same exact technology would work for blood clots," she says. "So we took the test we had developed before, which is an injectable nanoparticle, and made it a thrombin sensor."

The system consists of iron oxide nanoparticles, which the Food and Drug Administration has approved for human use, coated with peptides (short proteins) that are specialized to interact with thrombin. After being injected into mice, the nanoparticles travel throughout the body. When the particles encounter thrombin, the thrombin cleaves the peptides at a specific location, releasing fragments that are then excreted in the animals' urine.

Once the urine is collected, the protein fragments can be identified by treating the sample with antibodies specific to peptide tags included in the fragments. The researchers showed that the amount of these tags found in the urine is directly proportional to the level of blood clotting in the mice's lungs.

In the previous version of the system, reported last December in Nature Biotechnology, the researchers used mass spectrometry to distinguish the fragments by their mass. However, testing samples with antibodies is much simpler and cheaper, the researchers say.

Rapid screening

Bhatia says she envisions two possible applications for this kind of test. One is to screen patients who come to the emergency room complaining of symptoms that might indicate a blood clot, allowing doctors to rapidly triage such patients and determine if more tests are needed.

"Right now they just don't know how to efficiently define who to do the more extensive workup on. It's one of those things that you can't afford to miss, so patients can get an unnecessarily expensive workup," Bhatia says.

Another applica
'/>"/>

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Latest Research Findings for Autism
2. Novus International to Present Scientific Findings on Prebiotics during Aquaculture Europe 2013
3. Novartis highlights new findings in advancing care for patients with 170 abstracts in breast, lung and blood cancers at ASCO and EHA
4. Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers
5. Adult Acne Treatment, Probiotic Action Shares Insight on New Findings Between Probiotics and Heat Tolerance, and What It Means for Acne Sufferers
6. New Strain of Bacteria May Clear up Acne Probiotic Action Explains the New Research Findings from Washington University
7. Probiotic Action Comments on New Findings on Using Light Therapy to Fight Acne
8. Used-Line.com New Website Features Make Finding New and Used Test and Measurement and Lab Equipment Easier Than Ever
9. Galectin-3 Assessed as a Biomarker of Heart Failure: Key Clinical Trial Findings Published by Dove Medical Press
10. Fertility Associates of Memphis, World-Renowned Expert in Infertility, Presents Findings to European Conference
11. ENDECE Neural to Present Findings at 2013 Biotech Showcase on NDC-1308 which Induces Remyelination of Demyelinated Axons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... , Sept. 18, 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds ... Acetic Acid Industry" and "2014 Deep Research Report ... to its research database. Photo - ... Research Report on Global and China Acetic Acid ... on China and Global ...
(Date:9/18/2014)... 2014 Texas Governor Rick Perry, ... A&M Health Science Center CEO Brett Giroir, M.D., ... and Human Services (HHS), State of Texas and ... influenza vaccine manufacturing facility in Bryan, Texas, which ... the Texas A&M Biocorridor – a rapidly evolving ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global Human Albumin Industry Report 2014" report ... Albumin Industry Report 2014 is a professional and in-depth ... albumin industry. The report provides a basic ... industry chain structure. The human albumin market analysis is ...
(Date:9/18/2014)...  MEI Pharma, Inc. (Nasdaq: MEIP ), an ... for cancer, announced today that Daniel P. Gold , ... NewsMakers in the Biotech Industry conference on Friday, ... Millennium Broadway Hotel & Conference Center in New ... be accessed at www.meipharma.com . A replay will be ...
Breaking Biology Technology:Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3
... a self-powering cell phone that never needs to be ... user into the energy it needs to keep running. ... to the recent work of Tahir Cagin, a professor ... Texas A&M University. , Utilizing materials known in scientific ...
... announce that Matthew Heyman joined the organization as vice president of ... ... Rockville, Md. (Vocus) December 1, 2008 -- The ... Heyman joined the organization as vice president of external affairs and ...
... /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: BJGP ) ... will attend the 20th Annual Piper Jaffray Health Care,Conference. ... Annual Piper Jaffray Health Care Conference is being held ... at the New York,Palace Hotel in New York City. ...
Cached Biology Technology:Self-powered devices possible, says Texas A&M researcher 2Self-powered devices possible, says Texas A&M researcher 3USP Names Matthew Heyman Vice President of External Affairs and Strategic Integration 2USP Names Matthew Heyman Vice President of External Affairs and Strategic Integration 3
(Date:9/18/2014)... Mass. A novel robotic system that can operate ... being tested as part of a biomedical research partnership ... the aim of determining if the robot, in conjunction ... faster, more accurate, less costly, and less discomforting for ... to deliver prostate cancer therapies with greater precision. , ...
(Date:9/18/2014)... acquire and creatively manipulate spoken language is unique to ... 6 million years of human evolution to make this ... candidate gene we now have," says Wolfgang Enard, Professor ... efforts to understand the molecular biological basis of language ... results of his latest study, undertaken in collaboration with ...
(Date:9/18/2014)... seem to be cheerful, happy-go-lucky characters, so you might ... life. , In fact some dogs are distinctly ... Sydney shows. , "This research is exciting because ... objectively and non-invasively. It offers researchers and dog owners ... that changes," said Dr Melissa Starling, from the Faculty ...
Breaking Biology News(10 mins):Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3Dogs can be pessimists too 2Dogs can be pessimists too 3
... flatback turtles dine on fish, shrimp, and mollusks, ... sea turtles. New genetic research carried out by ... Center for Biodiversity and Conservation at the American ... understanding of the evolutionary relationships among all seven ...
... can be detected in a mineral likely present on ... a technique developed at the U.S. Department of Energy,s ... surface samples with the most promise for yielding signs ... of mineral and looks for chemical signatures of molecules ...
... optimize brain formation and function may also provide clues ... relapse, researchers say. Over the next two- and ... neurotrophic factor, or BDNF, in the blood of patients ... rise and fall is a good indicator that patients ...
Cached Biology News:Revealing the evolutionary history of threatened sea turtles 2Sensitive laser instrument could aid search for life on Mars 2Sensitive laser instrument could aid search for life on Mars 3Brain-nourishing molecule may predict schizophrenia relapse 2Brain-nourishing molecule may predict schizophrenia relapse 3
GLP-compliant, CLIA-certified DNA sequencing service. ASQ and SQA certified quality assurance staff. Auditors welcome....
Great for biotinylating DNA/RNA probes...
A component of the Acridinium protein labeling kit....
... polyclonal antibody to human XAB2 (amino terminus) ... identified through its interaction with XPA. Immunoprecipitation ... of XAB2 interacts with the transcription-coupled repair-specific ... with RNA polymerase II. Microinjection experiments with ...
Biology Products: