Navigation Links
Finding blood clots before they wreak havoc
Date:10/19/2013

CAMBRIDGE, Mass-- Life-threatening blood clots can form in anyone who sits on a plane for a long time, is confined to bed while recovering from surgery, or takes certain medications.

There is no fast and easy way to diagnose these clots, which often remain undetected until they break free and cause a stroke or heart attack. However, new technology from MIT may soon change that: A team of engineers has developed a way to detect blood clots using a simple urine test.

The noninvasive diagnostic, described in a recent issue of the journal ACS Nano, relies on nanoparticles that detect the presence of thrombin, a key blood-clotting factor.

Such a system could be used to monitor patients who are at high risk for blood clots, says Sangeeta Bhatia, senior author of the paper and the John and Dorothy Wilson Professor of Biochemistry.

"Some patients are at more risk for clotting, but existing blood tests are not consistently able to detect the formation of new clots," says Bhatia, who is also a senior associate member of the Broad Institute and a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science (IMES).

Lead authors of the paper are Kevin Lin, a graduate student in chemical engineering, and Gabriel Kwong, a postdoc in IMES. Other authors are Andrew Warren, a graduate student in Health Sciences and Technology (HST), and former HST postdoc David Wood.

Sensing thrombin

Blood clotting is produced by a complex cascade of protein interactions, culminating in the formation of fibrin, a fibrous protein that seals wounds. The last step of this process the conversion of fibrinogen to fibrin is controlled by an enzyme called thrombin.

Current tests for blood clotting are very indirect, Bhatia says. One, known as the D-dimer test, looks for the presence of fibrin byproducts, which indicates that a clot is being broken down, but will n
'/>"/>

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Latest Research Findings for Autism
2. Novus International to Present Scientific Findings on Prebiotics during Aquaculture Europe 2013
3. Novartis highlights new findings in advancing care for patients with 170 abstracts in breast, lung and blood cancers at ASCO and EHA
4. Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers
5. Adult Acne Treatment, Probiotic Action Shares Insight on New Findings Between Probiotics and Heat Tolerance, and What It Means for Acne Sufferers
6. New Strain of Bacteria May Clear up Acne Probiotic Action Explains the New Research Findings from Washington University
7. Probiotic Action Comments on New Findings on Using Light Therapy to Fight Acne
8. Used-Line.com New Website Features Make Finding New and Used Test and Measurement and Lab Equipment Easier Than Ever
9. Galectin-3 Assessed as a Biomarker of Heart Failure: Key Clinical Trial Findings Published by Dove Medical Press
10. Fertility Associates of Memphis, World-Renowned Expert in Infertility, Presents Findings to European Conference
11. ENDECE Neural to Present Findings at 2013 Biotech Showcase on NDC-1308 which Induces Remyelination of Demyelinated Axons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... CA (PRWEB) , ... September ... ... announced the launch of the new ImageXpress® Micro Confocal High-Content Imaging System. ... especially emerging assays that use 3D cellular models such as spheroids, tissues, ...
(Date:9/1/2015)... ... 01, 2015 , ... Leading CEOs, CSOs, CMOs, and heads ... join prominent academics and key investors for Neuro Advance Boston, October 14, 2015 ... , Neuro Advance Boston focuses on the latest developments and opportunities in ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... University of California Los Angeles, Boston University School of Medicine, Frederick National Laboratory ... PLOS One, the world’s first multidisciplinary Open Access journal. , Christopher Ryan ...
(Date:8/31/2015)... Pune (PRWEB) , ... August 31, 2015 , ... ... in various industries because of its properties such as low carbon footprints and ... by the use of petroleum based plastics. On the basis of applications, the ...
Breaking Biology Technology:ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 3Neuro Advance Boston Brings Together Leading Neuroscience Experts on October 14 at Harvard Medical School 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5
... , ... CEO, Matthew Sarad, plans a series of experiments to demonstrate the power of nanotechnology ... ... Mr. Matthew Sarad, has announced plans to attempt to rejuvenate living animals with advanced ...
... HORSHAM, Pa., Sept. 10 Centocor Ortho Biotech Products, L.P. ... U.S. Food and Drug Administration (FDA) regarding its Supplemental New Drug ... in combination with docetaxel for the treatment of women with ... Centocor Ortho Biotech is evaluating the FDA,s letter and ...
... , ABBOTT PARK, Ill. and MENLO ... announced today a definitive agreement to acquire the outstanding equity of ... minimally invasive repair of cardiac mitral valves. The acquisition provides ... for structural heart disease, in which physicians use catheter-based devices to ...
Cached Biology Technology:Matthew Sarad to Reverse Aging and Cure Cancer 2Matthew Sarad to Reverse Aging and Cure Cancer 3Matthew Sarad to Reverse Aging and Cure Cancer 4Centocor Ortho Biotech Receives FDA Complete Response Letter Regarding DOXIL(R) for the Treatment of Advanced Breast Cancer 2Centocor Ortho Biotech Receives FDA Complete Response Letter Regarding DOXIL(R) for the Treatment of Advanced Breast Cancer 3Centocor Ortho Biotech Receives FDA Complete Response Letter Regarding DOXIL(R) for the Treatment of Advanced Breast Cancer 4Centocor Ortho Biotech Receives FDA Complete Response Letter Regarding DOXIL(R) for the Treatment of Advanced Breast Cancer 5Abbott to Acquire Evalve, Inc., a Leader in Minimally Invasive Cardiac Valve Repair Technology 2Abbott to Acquire Evalve, Inc., a Leader in Minimally Invasive Cardiac Valve Repair Technology 3Abbott to Acquire Evalve, Inc., a Leader in Minimally Invasive Cardiac Valve Repair Technology 4
(Date:8/20/2015)... 20, 2015 The wearable technology market ... active and healthy. However, wearable technology has the ... to help improve diagnostic capabilities and therapeutic outcomes. ... Wearable Technologies Conference 2015 , where ... wearables in healthcare.    "Over the ...
(Date:8/18/2015)... 18, 2015  Navitas today announced that ... the Submission Content Management webinar scheduled on ... forum. Dedicated to the Implementation of Regulatory Submission ... for industry, vendors, health authorities, consultants and ... towards a standard method of implementing electronic ...
(Date:8/12/2015)... , August 12, 2015 As ... mobile payment innovation and advanced biometrics technology is accelerating ... way consumers rely on using their credit cards, the ... the future for payment services led by companies in ... ), :  Google, Inc. (NASDAQ: GOOG ), Apple ...
Breaking Biology News(10 mins):Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... CHAPEL HILL Researchers at the University of North Carolina ... reconstructed the bat variant of the SARS coronavirus (CoV) that ... say designing and synthesizing the virus is a major step ... for any strain of SARS virus that might affect humans ...
... Swedish research group, partly financed by NWO, has discovered a ... extremely hot and acidic conditions. The results of the research ... the human body. The research has been recently published in ... of Sciences. Thijs Ettema, member of the research group, received ...
... If you,re a cancer cell, you want a protein ... live or die. It,s usually a trusted bodyguard, protecting cancer ... form tumors. But sometimes it turns into their assassin. ... to actually cause such a betrayal. Now they do. And ...
Cached Biology News:Researchers recreate SARS virus, open door for potential defenses against future strains 2Proteins strangle cell during division 2Cancer cell 'bodyguard' turned into killer 2
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... Chamber lid allows easy gel observation and provides ... easy set up between power supply and migration ... if the lid is removed at the migration ... Remote control can be easily operated in ...
... have low background fluorescence, minimal light ... (or medium binding) polystyrene surface is ... through passive interactions,• Is suitable ... molecules, such as antibodies, that have ...
... Model 1575 immunowash microplate washer 100-240 V, ... have flat-, U-, or V-bottom wells. The ... and vertical needle positions to an accuracy ... aspiration, and overflow washing. It can store ...
Biology Products: