Navigation Links
Finding a protective mechanism for retinal cells could save sight

Determining what triggers the death of retinal cells, called photoreceptors, could hold the key to stopping blinding disorders caused by a wide range of eye diseases, Yale School of Medicine researchers report in the November journal Investigative Ophthalmology & Visual Science.

Several blinding disorders are known to cause the breakdown of photoreceptors. Caroline Zeiss, associate professor of comparative medicine and ophthalmology at Yale School of Medicine, and her colleagues sought to identify a mechanism in photoreceptors that could be targeted to prolong their survival. Using preserved animal and human retinal tissue, they studied different diseases with a range of genetic mutations that caused photoreceptor death, such as age-related macular degeneration and retinal pigmentosa.

In the diseases Zeiss and her team studied, photoreceptors died from a variety of causes, but the team found that all of the diseases had one common elementactivation of a family of molecules called CREB1/ATF1. It was unclear, however, whether CREB1/ATF1 contributed to photoreceptor loss, or was an attempt by photoreceptors to delay their death. To differentiate between these two possibilities, the team examined CREB1/ATF1 in retinas treated with a drug known to preserve photoreceptors. Protected photoreceptors expressed much higher amounts than unprotected retinas, suggesting that CREB1/ATF1 was part of the protective mechanism.

"Not only did we find that the drug activated the novel CREB1/ATF1 photoreceptor pathway, but we found that this activation was caused by stress," said Zeiss. "This suggests that CREB/ATF1 may be an innate protective response that could be used to achieve broad spectrum preservation of the retina."

"This is the first time that any protective signal within photoreceptors has been identified across such a broad range of eye diseases," Zeiss added. "By finding a common way in which photoreceptors react to stress, it may be possible to develop new therapies to preserve vision."

Zeiss said the next step in the research is to try to identify drug targets that could activate the CREB1/ATF1 pathway. The team could potentially screen thousands of compounds and look at their ability to turn on CREB1/ATF1 in retinal tissue.


Contact: Karen N. Peart
Yale University

Related biology technology :

1. New findings could help hybrid, electric cars keep their cool
2. Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference
3. Innocoll Announces Provisional Findings From Its Three Phase 2 Clinical Trials Investigating CollaRx(R) GENTAMICIN TOPICAL for the Treatment and Prevention of Diabetic Foot Infections
4. Recent Graduates Finding BioTech & Pharmaceutical Jobs Easier Than Ever With The Launch of CampusRXBio
5. Maryland Business, Academic and Biopharma Groups Underscore Commitment to Medical Innovation, Finding Cures and Supporting the Economy
6. Gene Therapy Field Advances With Important Clinical Findings Reported in the New England Journal of Medicine
7. Bionovo to Present Recent Findings of BN107, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium
8. Interleukin Genetics to Present New Findings on Osteoporosis at the 58th Annual Meeting of the American Society of Human Genetics
9. New Study Provides Key Findings for Biopharma Product Launch Evaluation
10. Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium
11. Helix BioPharma to Present L-DOS47 Research Findings at the National Research Council of Canadas Eighth Annual General Meeting of the Genomics and Health Initiative in Saskatoon, Canada
Post Your Comments:
(Date:11/25/2015)... , November 25, 2015 ... Research Report is a professional and in-depth study ...      (Logo: ) , ... of the industry including definitions, classifications, applications and ... provided for the international markets including development trends, ...
(Date:11/24/2015)... ... ... The United States Golf Association (USGA) today announced Dr. Bruce Clarke, of ... since 1961, the USGA Green Section Award recognizes an individual’s distinguished service to the ... of Iselin, N.J., is an extension specialist of turfgrass pathology in the department of ...
(Date:11/24/2015)... 2015 /CNW/ - iCo Therapeutics ("iCo" or "the Company") ... for the quarter ended September 30, 2015. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... said Andrew Rae , President & CEO ... not only value enriching for this clinical program, ...
(Date:11/24/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) (the ... the Toronto Stock Exchange, confirms that as of the ... developments that would cause the recent movements in the ... --> About Aeterna Zentaris Inc. ... Aeterna Zentaris is a specialty biopharmaceutical company engaged in ...
Breaking Biology Technology:
(Date:11/12/2015)... CAMBRIDGE, Mass. , Nov. 12, 2015 /PRNewswire/ ... Broad Institute of MIT and Harvard for use ... chemical discovery information management tools. The partnership will ... share both biological and chemical research information internally ... tools will be used for managing the Institute,s ...
(Date:11/9/2015)... , Nov. 09, 2015 ... the addition of the "Global Law ... their offering. --> ) ... "Global Law Enforcement Biometrics Market 2015-2019" ... Research and Markets ( ) has ...
(Date:10/29/2015)... , Oct. 29, 2015  The J. Craig Venter ... titled, "DNA Synthesis and Biosecurity: Lessons Learned and Options ... of Health and Human Services guidance for synthetic biology ... --> --> ... has the potential to pose unique biosecurity threats. It ...
Breaking Biology News(10 mins):