Navigation Links
Finding Brings Scientists One Step Closer To Parkinson's Drug
Date:6/26/2012

GRAND RAPIDS, Mich., June 27, 2012 /PRNewswire/ -- Van Andel Institute announces that researchers at Lund University in Sweden have published a study detailing how Parkinson's disease spreads through the brain. Experiments in rat models uncover a process previously used to explain mad cow disease, in which misfolded proteins travel from sick to healthy cells.

"A major unmet medical need is a therapy that slows disease progression," said Patrik Brundin M.D., Ph.D., Jay Van Andel Endowed Chair in Parkinson's Research at Van Andel Research Institute (VARI), Head of the Neuronal Survival Unit at Lund University and senior author of the study. "We aim to better understand how Parkinson's pathology progresses and thereby uncover novel molecular targets for disease-modifying treatments."

Previous research demonstrates that a misfolded protein gradually appears in healthy neurons transplanted to the brains of Parkinson's patients.  In the current study, published this week in the Public Library of Science (PLoS) One, researchers were able to follow events in the recipient cell as it accepts the diseased protein. The experiments also show how the transferred proteins attract proteins in the host cell leading to abnormal folding or "clumping" inside the cells.

"This is a cellular process likely to lead to the disease process as Parkinson's progresses, and it spreads to an increasing number of brain regions as the patient gets sicker," said Elodie Angot, Ph.D., of Lund University's Neuronal Survival Unit, and lead author of the study.

Link to the study here:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039465

Neuronal Survival Unit, Faculty of Medicine, Lund University

The research at Neuronal Survival Unit, Lund University, Sweden is focused on pathogenetic mechanisms and pharmacological treatment in cell and animal models of Parkinson's and Alzheimer's diseases. The group's mission is to understand neurodegenerative diseases and develop new therapies that are of benefit to patients and their caregivers. http://www.med.lu.se/expmed/neuronal_survival_unit

Van Andel Institute

Van Andel Institute is an independent research organization dedicated to preserving, enhancing and expanding the frontiers of medical science, and to achieving excellence in education by probing fundamental issues of education and the learning process. This is accomplished through the work of over 200 researchers and in collaborative partnerships that span the globe. www.vai.org

www.vai.org

Facebook

Twitter

YouTube


'/>"/>
SOURCE Van Andel Institute
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients
2. 23andMe Provides the Science Behind PBS Series "Finding Your Roots with Henry Louis Gates, Jr." With Its Personal Genome Service®
3. Profil Institute Continues to Publish New Findings in Metabolic Research
4. Expanded Findings for FirstMarks Completed Clinical Study for Predicting Near-Term (2-3 Years) MI
5. Social networking shortcut to finding medical experts
6. GeoVax Labs Presents New Findings on Potential HIV Vaccine at 2012 Conference on Retroviruses and Opportunistic Infections (CROI)
7. Live Press Briefing on Findings of Biomedical Industry CEO Survey
8. 23andMe Presents Top Ten Most Interesting Genetic Findings of 2011
9. US Oncology Research Affiliated Physician to Present Findings From Innovative Clinical Trial at 2011 CTRC-AACR San Antonio Breast Cancer Symposium
10. Clionsky Neuro Systems (CNS-Neuro) Announces Publication of Study Finding Elderly Patients Unable to Recognize Their Memory Loss
11. Biodetection 2012 Conference Brings Together Leading Organizations from Around the World to Address Challenges & Technology Advances in Detection and Identification of Biological Threats in Washington, DC from June 28-29, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... Linda, Ca (PRWEB) , ... August 15, 2017 ... ... coffee production and is threatened by various biotic and abiotic factors. During this ... complex evolutionary history of coffee, as well as gain a better understanding of ...
(Date:8/14/2017)... , ... August 14, 2017 , ... ... essential device-to-computer interconnect using USB or PCI Express, announced the release of SYZYGY™, ... is intended to satisfy the need for a compact, low cost, low pin-count, ...
(Date:8/11/2017)... San Antonio, Texas (PRWEB) , ... August 11, 2017 , ... ... launching a rebranding campaign this month that will incorporate important key elements including a ... to thank the community that has supported them, Bill Miller has partnered with the ...
(Date:8/10/2017)... ... August 09, 2017 , ... As a full-service marketing agency, ... customers with the right message. Their effective, cutting-edge inbound marketing strategies are available ... how crucial the agriculture industry is,” said David Phelps, chief marketing officer at ...
Breaking Biology Technology:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):