Navigation Links
Fate Therapeutics Strengthens Its iPSC Platform
Date:11/16/2011

SAN DIEGO, Nov. 16, 2011 /PRNewswire/ -- Fate Therapeutics, Inc. announced today that the United States Patent and Trademark Office has granted a patent covering the novel stem cell modulator commonly known as Thiazovivin.  U.S. Patent No. 8,044,201 entitled "Stem Cell Cultures" claims Thiazovivin, a small molecule Rho-associated kinase (ROCK) inhibitor, as well as compositions and cell culture media comprising Thiazovivin.  Thiazovivin is crucial to the efficient generation of human induced pluripotent stem cells (iPSCs), and the survival of human embryonic stem cells (hESCs), in culture.  Fate Therapeutics holds an exclusive license from The Scripps Research Institute (TSRI) to the patent in all commercial fields.

"The generation, survival and expansion of pluripotent stem cells – without compromise to their self-renewal capacity and ultimate differentiation potential – remains critical to realizing the potential of stem cell biology-based therapeutics," said Dr. John Mendlein, Executive Chairman of Fate Therapeutics.  "We believe that our industrialized iPSC product engine, including our high throughput methods of reprogramming, cell selection, characterization and single-cell passaging, offers a powerful opportunity for stem cell research and drug discovery, and for the potential development of iPSC-derived cell therapies."

The importance of Thiazovivin in enabling an industrialized iPSC product platform was first elucidated by Sheng Ding, Ph.D., a scientific founder of Fate Therapeutics, while at TSRI.  Under a research collaboration between TSRI and Fate Therapeutics, Dr. Ding and his team of TSRI scientists first demonstrated that Thiazovivin, in combination with other small molecules, dramatically improves the reprogramming of human fibroblasts by 200-fold as compared to non-chemically enhanced methods of iPSC generation (Lin, T., et al, Nature Methods 6, 805 - 808 (2009)), and that Thiazovivin promotes the survival of hESCs after single-cell dissociation (Xu, Y., et al, PNAS 107(18): 8129-8134).  Thiazovivin is believed to be a critical factor in maintaining the stem cell niche during conditions that might otherwise be detrimental to cell viability.

About Fate Therapeutics, Inc.

Fate Therapeutics, Inc. interrogates stem cell biology to develop breakthrough therapeutics based on modulating cell fate and to enable a new drug discovery paradigm that includes proprietary induced-pluripotent stem (iPS) cell technology. The company's first therapeutic candidate is in clinical trials in hematopoietic reconstitution. Fate Therapeutics is a private company headquartered in San Diego, CA with a subsidiary in Ottawa, Canada. For more information, please visit www.fatetherapeutics.com.

About The Scripps Research Institute

The Scripps Research Institute is one of the world's largest independent, non-profit biomedical research organizations. Scripps Research is internationally recognized for its discoveries in immunology, molecular and cellular biology, chemistry, neuroscience, and vaccine development, as well as for its insights into autoimmune, cardiovascular, and infectious disease. Headquartered in La Jolla, California, the institute also includes a campus in Jupiter, Florida, where scientists focus on drug discovery and technology development in addition to basic biomedical science. Scripps Research currently employs about 3,000 scientists, staff, postdoctoral fellows, and graduate students on its two campuses. The institute's graduate program, which awards Ph.D. degrees in biology and chemistry, is ranked among the top ten such programs in the nation. For more information, see www.scripps.edu.

Fate Therapeutics, Inc.
Scott Wolchko
Chief Financial Officer
+1-858-875-1800
media@fatetherapeutics.com


'/>"/>
SOURCE Fate Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Halozyme Therapeutics Reports 2008 Second Quarter Financial Results
2. Repair Stem Cell Institute Announces Industrys First Standards of Excellence for Global Stem Cell Treatment Centers to Protect Patients from Less-than-Competent Therapeutics
3. Amsterdam Molecular Therapeutics Reports Half Year Results 2008
4. BN ImmunoTherapeutics Announces Partnership With National Cancer Institute
5. Arno Therapeutics Announces Appointment of Brian Lenz, CPA as Chief Financial Officer
6. CV Therapeutics Announces Ranexa(R) Named Finalist for Prix Galien USA 2008 Award
7. CV Therapeutics Receives European Approval for the Brand Name Ranexa(R)
8. Nile Therapeutics, Inc. Reports 2008 Second Quarter Financial Results
9. Cell Therapeutics, Inc.s Second Quarter 2008 Financial Results
10. Logical Therapeutics Inc. Announces Results of Phase 1b Clinical Study of its Naproxen Prodrug
11. Arno Therapeutics Announces Second Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... BioAmber Inc. (NYSE: BIOA ) announced today that Jean-Francois Huc ... company,s COO, has been named President, effective immediately.  ... has overseen the construction, start-up and operation of the manufacturing plant ... Mitsui JV.  Fabrice has also been extensively involved in the negotiations ... ...
(Date:2/20/2017)... ... 20, 2017 , ... Salford-based Mettler Toledo Safeline, which employs ... processing and packaging industries, was runner-up for the Environmental Achievement Award, sponsored by ... or taken the most innovative steps to improve its environmental performance. , ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... patients, prevent chest wall collapses in pre-term infants with respiratory distress, and ... total of $600,000 in funding through the ninth round of the University ...
(Date:2/20/2017)... 20, 2017  At the 2017 Health Information ... Orlando , IBM (NYSE: IBM ) ... IBM Chairman, President and CEO Ginni Rometty ... today from 8:30-10 am ET, broadcast live on ... Her remarks examine the advent of the Cognitive ...
Breaking Biology Technology:
(Date:1/26/2017)... , Jan. 26, 2017  Crossmatch, a leading ... a new solution aimed at combatting fraud, waste and ... was introduced at the Action on Disaster Relief conference ... meeting point for UN agencies and foreign assistance organizations ... Fraud, waste and abuse are a largely unacknowledged problem ...
(Date:1/23/2017)... , Jan. 23, 2017  The latest mobile ... smartphone prices have dropped dramatically. The quarterly average price ... 2013 to $276 in Q4 2016.  There are now ... price of $116, up from just 28 a year ... According to Maxine Most , Acuity Market ...
(Date:1/18/2017)... , Jan. 18, 2017 ... company that supports the entire spectrum of clinical ... been another record-breaking year for the organization in ... interest in MedNet,s eClinical products and services. The ... tremendous marketplace success of iMedNet ...
Breaking Biology News(10 mins):