FMC Corporation and Pronova BioPharma Announce Agreement To Develop New Alginate-Based Capsul...(ionknown as hypertriglyceridemia (HTG) a...)

Date:12/14/2007

ion known as hypertriglyceridemia (HTG), a form of dyslipidemia (or disorder of lipid metabolism). Very high triglycerides have been linked to a number of cardiovascular diseases. Omacor is also approved in key European and certain Asian markets for the secondary prevention of post-myocardial infarction, or Post-MI, the period following the initial survival of a heart attack.

Omacor/Lovaza has been demonstrated in a number of clinical trials to be a potent triglyceride-lowering agent as a monotherapy. It has been documented to be efficacious, safe, and highly complementary to other lipid-lowering agents, such as statins, and can be used in concomitant treatment for mixed dyslipidemia. In addition, Pronova BioPharma is involved in various projects to develop Omacor/Lovaza in a number of cardiovascular indications, including as a combination therapy with statins for mixed dyslipidemia, which the management of Pronova BioPharma believes represents a major market opportunity for the company.

Pronova BioPharma's global network of license and distribution partners includes: Reliant Pharmaceuticals (U.S.), Takeda Pharmaceutical (Japan), Prospa (Italy) and Solvay (U.K., Germany and others). The combined sales force from this network focused on the sale of Omacor/Lovaza is over 1,750 sales representatives, of which approximately 600 are employed by Reliant Pharmaceuticals in the United States.

Omacor/Lovaza was launched in 2005 in the United States and in major European markets, such as France and Spain. IMS Health reports that global end-user sales of the product have increased from US$144 million in 2005 to US$306 million in 2006. The current annual run rate for end-user sales is estimated at US$500 million, and Pronova BioPharma estimates that approximately 600,000 patients are currently on a prescription for Omacor/Lovaza.

Pronova BioPharma is listed at Oslo Bors. See http://www.pronova.com fo
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SOURCE FMC Corporation Copyright©2007 PR Newswire. All rights reserved

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