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MDD is a serious medical condition that is different from "feeling
blue" and is not something that people just "get over." Criteria for MDD
include five or more of the following symptoms that have been present for
at least two weeks, and at least one of the symptoms must be either
depressed mood or loss of interest or pleasure: depressed mood; loss of
interest or pleasure; changes in appetite or weight; changes in sleeping
patterns; psychomotor agitation or retardation; fatigue or low energy;
feeling worthless or guilty for no reason; difficulty thinking or
concentrating; or thoughts of death or suicide. Further, people with MDD
must experience clinically significant distress or impairment in social,
occupational or other important areas of functioning.
Important Treatment Considerations for Antidepressants
Suicidality and Antidepressant Drugs
-- Antidepressants increased the risk compared to placebo of suicidal
thinking and behavior (suicidality) in children, adolescents, and young
adults in short-term studies of major depressive disorder (MDD) and
other psychiatric disorders.
-- Depression and certain other psychiatric disorders are themselves
associated with increases in the risk of suicide.
-- Patients of all ages who are started on antidepressant therapy should
be monitored appropriately and observed closely for clinical worsening,
suicidality, or unusual changes in behavior, especially when starting
therapy or at times of dose changes.
-- PRISTIQ is not approved for use in pediatric patients.
Important Treatment Considerations for PRISTIQ
-- PRISTIQ is indicated for the treatment of major depressive disorder in
adults.
Contraindications
-- PR
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