Side effects of many antidepressant therapies can cause some patients to stop taking their medication. The most commonly observed adverse reactions in patients taking PRISTIQ for MDD in short-term, fixed-dose studies (incidence greater than or equal to 5 percent and at least twice the rate of placebo in the 50 or 100 mg dose groups) were nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence (sleepiness), decreased appetite, anxiety, and specific male sexual function disorders.
PRISTIQ delivers the major active metabolite of EFFEXOR XR(R) (venlafaxine HCl) in its active state without going through the CYP2D6 metabolic pathway. This could be beneficial when PRISTIQ is coadministered with other commonly prescribed medications metabolized through that pathway. EFFEXOR XR, discovered and developed by Wyeth, was the first SNRI approved by the FDA for MDD and is currently the most widely prescribed antidepressant in the world.
PRISTIQ, also discovered and developed by Wyeth, demonstrates the Company's significant and continued commitment to developing new therapies in the field of neuroscience.
About Major Depressive Disorder
Major depressive disorder (MDD) is a common mental disorder, affecting
about 121 million people worldwide. In the United States, MDD affects
approximately 15 million adults, or 6.7 percent of the U.S. population age
18 and older in a given year. In fact, depression is among the leading
causes of disability and the fourth leading contributor to the global
burden of disease. Further,
|SOURCE Wyeth Pharmaceuticals|
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