Navigation Links
FDA Approves IXEMPRA(TM) (ixabepilone), a Semi-Synthetic Analog of Epothilone B, for the Treatment of Advanced Breast Cancer
Date:10/16/2007

ade 3/4: 54%) and leukopenia (Grade 3/4: 49%).

(Phase III, Combination Trial: -046) The randomized Phase III trial evaluated the efficacy and safety of IXEMPRA in combination with capecitabine in comparison with capecitabine as monotherapy. This trial included 752 patients who were previously treated with anthracyclines and taxanes, and whose tumors had demonstrated prior resistance to these therapies. Anthracycline resistance is defined as progression while on therapy or within six months in the adjuvant setting, or three months in the metastatic setting. Taxane resistance is defined as progression while on therapy or within 12 months in the adjuvant setting or four months in the metastatic setting. Evaluation of the primary endpoint demonstrated that IXEMPRA in combination with capecitabine resulted in a statistically significant improvement in progression-free survival compared to capecitabine monotherapy - median 5.7 (95% CI, 4.8-6.7) vs. 4.1 months (95% CI, 3.1-4.3); P<0.0001, Hazard ratio=0.69 (95% CI, 0.58-0.83).

Treatment-related non-hematological adverse events (greater than or equal to 20%) reported in patients treated with IXEMPRA in combination with capecitabine included: peripheral sensory neuropathy 65% (Grade 3/4: 21%), palmar-plantar erythrodysesthesia (hand-foot) syndrome 64% (Grade 3/4: 18%), fatigue/asthenia 60% (Grade 3/4: 16%), nausea 53% (Grade 3/4: 3%), diarrhea 44% (Grade 3/4: 6%), vomiting 39% (Grade 3/4: 4%), myalgia/arthralgia 39% (Grade 3/4: 8%), anorexia 34% (Grade 3/4: 3%), stomatitis/mucositis 31% (Grade 3/4: 4%), alopecia 31% (Grade 3/4: 0%), abdominal pain 24% (Grade 3/4: 2%), nail disorder 24% (Grade 3/4: 2%), musculoskeletal pain 23% (Grade 3/4: 2%), and constipation 22% (Grade 3/4: 0%). Treatment-related hematological adverse events (greater than or equal to 20%) reported in patients treated with IXEMPRA in combination with capecitabine included: neutropenia (Grade 3/4: 68%) and leukopenia (Grade 3/4: 57%).

Compa
'/>"/>

SOURCE Bristol-Myers Squibb Company
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. UW-Madison approves new research institute
2. FDA approves GEs heart-imaging technology
3. Senate approves bill to expand stem cell funding
4. FDA approves advanced digital mammography system
5. Building commission approves Institutes for Discovery
6. UW Board of Regents approves $134 million medical research facility
7. FDA approves Bone Cares Hectorol for treatment of kidney disease
8. Analog people in the Digital Revolution, part II
9. Analog people in the digital revolution
10. Unique Surface Treatment of Novel TSK-GEL ODS Columns Provide Separation of Aqueous and Fat Soluble Vitamins
11. Improve Recovery and Reproducibility with Pre-Treatment of Analytical TSK-GEL G3000SWXL Size Exclusion Columns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... , Oct. 30, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... announced that management will present a company overview at the ... a.m. ET in Boston, MA. ... on the "Investors & Media" section of the Company,s website, ... Isis website within 48 hours and will be archived for ...
(Date:10/27/2014)... North Carolina (PRWEB) October 27, 2014 ... invited earlier this month to sit down with Bryan Hamilton, ... from RPG Solutions to discuss talent in the Research Triangle ... topics that were highlighted at the roundtable include ... the Triangle, the significance of work/life balance and the unique ...
(Date:10/27/2014)... 27, 2014 The “Molecular Diagnostic ... Microbiology), Technology (PCR, INAAT, DNA Sequencing), End User ... Software) - Global Forecast to 2018” provides a ... opportunities, current market trends, and strategies impacting the ... and forecasts of the revenue and share analysis. ...
(Date:10/27/2014)... Janssen Biotech, Inc. and the Crohn,s ... the launch of Get Your Full ... designed to provide resources for people living with ... of nutrition and appropriate therapy in managing IBD. ... with this release, please click: http://www.multivu.com/players/English/7261131-janssen-ccfa-get-your-full-course-for-ibd-wellness-with-sunny-anderson/ ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4
... , , , ... ("Rib-X" or the "Company"), a development-stage company focused on ... the treatment of acute care antibiotic-resistant infections, today announced ... the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy ...
... ... MGi scientific camera is being launched into space today as part of ... Naval research Laboratory (NRL) chose the Rolera MGi because of its high ... NASA will transmit the data to the NRL, which will then distribute ...
... In the news release, "Clinical Therapeutics Announces ... for a Refocused Pediatric,Adolescent, & Maternal Therapeutics Section" issued ... PR Newswire, we are advised by a representative,of the ... England",to "Bridgewater, New Jersey" and the contact number has ...
Cached Biology Technology:Rib-X Pharmaceuticals to Present at the 49th ICAAC 2Rib-X Pharmaceuticals to Present at the 49th ICAAC 3Rib-X Pharmaceuticals to Present at the 49th ICAAC 4First Spaceborne Hyperspectral Imager Will Use QImaging Rolera-MGi EMCCD Camera 2/C O R R E C T I O N -- Clinical Therapeutics/ 2/C O R R E C T I O N -- Clinical Therapeutics/ 3/C O R R E C T I O N -- Clinical Therapeutics/ 4/C O R R E C T I O N -- Clinical Therapeutics/ 5
(Date:10/28/2014)... from the National University of Singapore (NUS) have discovered ... breeding and laying direct developing eggs in live bamboo ... white spotted bush frog ( Raorchestes chalazodes ). ... two species known to adopt this novel reproductive strategy. ... London,s Biological Journal of the Linnean Society , ...
(Date:10/27/2014)... punch with a pair of papers that detail how ... Collagen is the most common protein in mammals, a ... support cells and hold organs together. Discovering its secrets ... and cosmetic and reconstructive medicine. , The Rice lab ... a decade, teasing out the details of how it ...
(Date:10/27/2014)... – October 28, 2014 – A new randomized controlled ... blend of collagen and calcium, KoACT®, was far superior ... leaching of calcium from bones and rebuilding new bone ... at: http://www.ncbi.nlm.nih.gov/pubmed/25314004 , ahead of print in ... research was conducted by Bahram H. Arjmandi, PhD, RDN, ...
Breaking Biology News(10 mins):NUS researchers discover for the first time that a rare bush frog breeds in bamboo 2NUS researchers discover for the first time that a rare bush frog breeds in bamboo 3'Sticky' ends start synthetic collagen growth 2'Sticky' ends start synthetic collagen growth 3New RCT: KoACT® beats calcium and vitamin D for optimal bone strength 2
... would happen if a fast-food restaurant reduces the calories ... decreasing the portion size of French fries? Would children ... beverage? Researchers at Cornell University, Dr. Brian Wansink and ... McDonald,s restaurants to answer that question. Prior to ...
... predict sinkholes? What do ancient ambers reveal about paleochemotaxonomy? ... us understand current global warming? Did trilobites venture into ... above sea level? What does the 27 March 2013 ... you reconstruct snapshots of a catastrophic radial current? What ...
... The wild bison roaming Catalina Island are a major attraction ... Island,s most popular destination every year. But managing the number ... endanger the health of the rest of the Island has ... new study by the Catalina Island Conservancy scientists, published in ...
Cached Biology News:Healthier Happy Meals 2New geology research explores intriguing questions 2New geology research explores intriguing questions 3New geology research explores intriguing questions 4New geology research explores intriguing questions 5New geology research explores intriguing questions 6New geology research explores intriguing questions 7New geology research explores intriguing questions 8New geology research explores intriguing questions 9Study finds Catalina Island Conservancy contraception program effectively manages bison population 2