Navigation Links
FDA Approves Administration of LEXIVA(R) with Lower Dose of 'Boosting' Medication Ritonavir
Date:10/12/2007

Data Show Lower Dose Associated with Fewer Adverse Events in Healthy

Volunteers

RESEARCH TRIANGLE PARK, N.C., Oct. 12 /PRNewswire-FirstCall/ -- GlaxoSmithKline's (NYSE: GSK) HIV protease inhibitor LEXIVA(R) (fosamprenavir calcium) may now be administered with 100mg of ritonavir, an agent that increases, or boosts, the level of protease inhibitors in the bloodstream.

The U.S. Food and Drug Administration approved once-daily LEXIVA 1400 mg with 100mg of ritonavir in adult patients who had not previously taken a protease inhibitor (PI). The approval was based on pharmacokinetic data demonstrating comparable blood plasma levels in healthy volunteers when LEXIVA was administered with the lower 100mg dose of ritonavir and the previously approved 200mg dose of ritonavir. This information has been added to the LEXIVA product label.

LEXIVA is indicated in combination with other antiretrovirals for the treatment of HIV infections. Ritonavir works with LEXIVA and other protease inhibitors to boost the medication level in the bloodstream making the protease inhibitor more effective in suppressing HIV. HIV medicines do not cure HIV infections/AIDS or prevent passing HIV to others.

"GlaxoSmithKline remains committed to improving patient care by making dosing options more convenient," said Mark Shaefer, Pharm. D., Director, Clinical Development at GlaxoSmithKline. "We understand that reducing the number of pills taken daily is an important consideration for patients starting HIV treatment."

The data supporting this label change were published in the February 2007 issue of Antimicrobial Agents and Chemotherapy.

LEXIVA Indication Statement and Background

LEXI
'/>"/>

SOURCE GlaxoSmithKline
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. UW-Madison approves new research institute
2. FDA approves GEs heart-imaging technology
3. Senate approves bill to expand stem cell funding
4. FDA approves advanced digital mammography system
5. Building commission approves Institutes for Discovery
6. UW Board of Regents approves $134 million medical research facility
7. FDA approves Bone Cares Hectorol for treatment of kidney disease
8. Lowering the fear factor for entrepreneurs, intra-preneurs
9. Immune boosting beverage relying on Milwaukee firms packaging technology
10. GE Healthcare develops digital medication system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... Diego, California (PRWEB) January 22, 2015 ... Promotional Offer to their comprehensive portfolio of Eppendorf ... allows customers to purchase a Centrifuge 5424/5424 R and ... Bundle of either Eppendorf Research plus or Eppendorf Reference ...
(Date:1/22/2015)... Diagenode, Inc., a leading global ... and complete solutions for epigenetics research, recently launched ... the need for manual processing. The new ChIPettor ... of histones or transcription factors and a semi-automated ...
(Date:1/22/2015)...  Derma Sciences, Inc. (Nasdaq: DSCI ), ... care, announces that AMNIOEXCEL® and AMNIOMATRIX®, amniotic allografts ... the Premier, Inc. Regenerative Skin Grafting contract portfolio. ... and AMNIOMATRIX® product lines, which continue to be ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... Wellcome Clinical Scholar, Department of Veterinary,Pathology, University of Glasgow, Bearsden Rd, Glasgow. G61 1QH. , ... Introduction , A method that ... of tissues for analysis in the Polymerase Chain Reaction is described. ... with a low risk of inadvertent contamination , ...
... , Prepare DNA from blood, cultured cells, or ... at 56C for 1530 min, then , boil for 8 ... an improved , substrate for PCR amplification. , ... Use whole blood samples that are frozen, refrigerated, or collected fresh. , ...
... Genomic DNA Isolation Kit , Catalog #732-6340 , ... Method , Cell Lysis , ... , at -70 to -80C. Fresh tissue may also be used. ... times including when tissue is weighed. , 2. Add 510 mg (0.0050.01 ...
Cached Biology Technology:Preparation of PCR Quality Template DNA from a Wide Range of Tissues Using InstaGene Matrix 2Preparation of PCR Quality Template DNA from a Wide Range of Tissues Using InstaGene Matrix 3InstaGene Matrix: Prepare DNA Templates for PCR With No Phenol/Chloroform Extractions and No Deproteinization Steps, Rev C 2Genomic DNA Isolation From 510 mg Marine Invertebrate Tissue 2
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 Based ... 5S, Samsung introduces for the first time a fingerprint ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader ... PerformTek biometric technology to industry leaders such as Intel, ... clinically validated, biometric wearable products. These products will be ... Las Vegas . ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... of Medicine autism experts Fred Volkmar, M.D. and Ami Klin ... to identify a gene and a region of a chromosome ... are published online today in Nature Genetics and also will ... based on the largest-ever autism genome scan. Over 120 scientists ...
... idea that one cause of high blood pressure lies within ... been put forward by scientists at the University of Bristol, ... , Dr. Hidefumi Waki, working in a research group led ... the protein, JAM-1 (junctional adhesion molecule-1), which is located in ...
... School of Public Health have discovered a means for ... from serum samples as a baseline biomarker, the scientists ... been associated with the development of liver carcinomas. This ... for early detection of liver cancer in high-risk populations, ...
Cached Biology News:Autism gene identified by researchers at Yale working with a global research consortium 2Blame the brain for high blood pressure 2Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer 2
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Purified anti-DNA-PKcs Phosphorylated (Thr2609)...
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
... Antigen Afinity Purified Tyrosine ... polyclonal antibody was raised against ... acids residues surrounding the phospho-Ser40 ... The antibody was purified by ...
Biology Products: