Navigation Links
FASgen, Inc. Presents Ovarian Cancer Efficacy and Toxicology Data to the American Association for Cancer Research
Date:4/18/2008

BALTIMORE, April 18 /PRNewswire/ -- FASgen, Inc. presented at the AACR meeting in San Diego efficacy and toxicology data on FAS31, FASgen's lead compound for ovarian cancer. FAS31 is an inhibitor of fatty acid synthase (FASi), an enzyme that is highly expressed in many human cancers. Numerous studies have shown that pharmacological FAS inhibition is cytotoxic to a variety of human xenograft models without toxicity. In preliminary toxicity studies, FAS31 showed no observable toxicity in normal tissues in the rat or mouse.

FAS31 inhibits fatty acid synthesis in SKOV3 human ovarian cancer cells in vitro (IC-50 = 6.09 +/- 0.4 ug/ml) at a concentration similar to induce cytotoxicity (LC-50 = 5.2 +/- 2.0 ug/ml). FAS 31 (50 mg/kg/day) for 2 weeks substantially inhibited SKOV3 xenograft growth by >90% compared to vehicle. FAS activity in the treated tumor xenografts was reduced by 82%. This is consistent with published in vitro studies where inhibition of FAS pathway activity by at least 20% led to brisk apoptosis in human cancer cells. No gross or microscopic organ toxicity was identified.

In maximally tolerated dose studies, male and female rats were challenged with increasing single doses of FAS 31 ranging from 0 (vehicle) to 1000 mg/Kg ip or po and followed for 8 days. Aside from one death in the female rats treated with 1000 mg/Kg (ip), no overt toxicity was noted in any other animals; normal motor activity was recorded. In a five-day rat toxicology study, male and female rats were challenged with twice-daily doses of FAS 31 from 0 to 500 mg/Kg ip or orally. No abnormal behavior or distress was noted attributable to FAS 31. All chemistry and hematology studies were within normal limits.

The multiple successful mouse efficacy trials in human ovarian cancer cell lines, showing 80% reduction in SKOV-3 tumor xenografts, and the combination of toxicity, maximum tolerated dose, bioavailability and pK studies lead to the conclusions that FAS31 is e
'/>"/>

SOURCE FASgen, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Anthera Presents Data on Varespladib at ATVB Meeting
2. Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cancer Research
3. ProMetic presents preclinical data for prostate and pancreatic cancer at the AACR Meeting
4. NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the Annual Meeting of the American Association for Cancer Research (AACR); Scientific Advisory Board Chairman Tyler Jacks Named President-elect
5. Kosan Presents Preclinical Data on Novel Third-Generation Hsp90 Inhibitors at AACR
6. Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040
7. SGX Presents Preclinical MET Data at AACR
8. ARIUS presents new findings for anti-cancer antibody programs at AACR
9. Ardea Presents Preclinical Data on Novel Next Generation Non-Nucleoside Reverse Transcriptase Inhibitors Demonstrating Potent Anti-HIV Activity Against Resistant Viruses
10. MedImmune Presents Data Highlighting its Progressive Oncology Portfolio at Annual Meeting of the American Association For Cancer Research
11. Genetic Engineering and Biotechnology News (GEN) Presents Exclusive Podcast with Robert Langer, Ph.D. on New Polymeric Drug Delivery Systems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Boston, MA (PRWEB) August 29, 2014 Due ... (FRC) last week, the Adult Stem Cell Technology Center, ... donations to support stem cell therapy research that might benefit ... adult stem cells for new stem cell technologies and therapeutic ... ALS Ice Bucket Challenge donors who wish not ...
(Date:8/28/2014)... August 28, 2014 Best Sanitizers, Inc., ... the food processing industry, is asking industry professionals to ... comparison of the E2 soap they’re currently using to ... Soap . Hand hygiene is critical to fighting ... processing environment. Six key criteria are identified to evaluate ...
(Date:8/28/2014)... converters are important devices in spintronics, an electronic ... of electrons but also on their spin and ... of electric into magnetic signals and vice versa. ... from the Institute of Physics at Johannes Gutenberg ... UK, Prague, and Japan, has for the first ...
(Date:8/28/2014)... , Aug. 28, 2014   SunTrust Robinson Humphrey ... industry veterans to its equity research team in ... ongoing expansion in equity research demonstrates our commitment ... insights to enhance their investment decision making," said ... STRH.  "We continue to make significant investments in ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3
... an organizational meeting last week to name its leadership. ... Wisconsin institutions. , ,Tom Hefty, former co-chairman of the ... of directors. He is now with law firm Reinhart, ... dean of the UW-Madison College of Engineering , ...
... information officers made the Computerworld magazine's top-100 list this year. ... Manufacturing Co. , in Racine. Modine specializes in thermal management ... London and a carbon-dioxide-cooled Jeep, and has been active in ... CIO of ShopKo Stores Inc. , in Green Bay. ...
... Wis. The invention of three Medical College ... patients' brains. Kyron Clinical Imaging Inc. received FDA clearance ... the Milwaukee Journal-Sentinel reported . , ,Kyron's software would ... MRI, scanner. A sample image released by the company ...
Cached Biology Technology:
(Date:8/31/2014)... new study, published today in Nature Climate Change , ... alone will reach, if not exceed, the global targets for ... study,s authors say we should all think carefully about the ... healthier diets across the world is just one of a ... dangerous climate change and ensure there is enough food for ...
(Date:8/31/2014)... in French . ... in the prestigious Nature Neuroscience journal by, Sylvain ... the Douglas Mental Health University Institute and McGill University, opens ... dynamic mechanisms controlling memory as well of the role of ... the subiculum. , In 2009, they developed a unique ...
(Date:8/29/2014)... 2014) Scientists at the Barshop Institute for Longevity ... at the UT Health Science Center at San Antonio, ... of the longest-lived rodent, the naked mole rat. ... of naked mole rats protects and alters the activity ... obsolete proteins. , The factor also protects proteasome function ...
Breaking Biology News(10 mins):Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2Factor in naked mole rat's cells enhances protein integrity 2
... preterm infants may not be fully protected against invasitve ... The findings are reported in the November issue of ... The study, conducted by researchers from Newcastle University, began ... The survey found that preterm infants at increased risk ...
... Four researchers at the U.S. Department of ... have been awarded a total of 65 million ... Gene/P ("Intrepid") supercomputer. The researchers will conduct advanced ... be almost impossible and impractical in the natural ...
... VA Age-related hearing loss (ARHL), one of the four ... low serum levels of folic acid, according to new research ... Head and Neck Surgery . Hearing loss is ... million Americans between the ages of 60 and 74 dealing ...
Cached Biology News:Argonne scientists awarded supercomputing time to enable scientific breakthroughs 2Argonne scientists awarded supercomputing time to enable scientific breakthroughs 3Argonne scientists awarded supercomputing time to enable scientific breakthroughs 4
...
... Capture Plate is a 96-well ELISA-compatible plate (containing ... Tail Fiber Monoclonal Antibody is immobilized by a ... specifically recognizes the tail fiber protein of the ... capacity of 10 9 phage per well ...
Kit for testing the ability of a compound to simulate lipolysis in cultured human adipocytes. Kit contains controls, buffers and reagents for detecting glycerol and non-esterified free fatty acids. A...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
Biology Products: