Navigation Links
Expanding drug development horizons: Receptor behaviors observed in living cell membranes
Date:2/16/2011

Kyoto, Japan -- Unprecedented single molecule imaging movies of living cell membranes, taken by a research team based at Kyoto University and the University of New Mexico, have clarified a decades-old enigma surrounding receptor molecule behaviors. The results, appearing in the latest issue of the Journal of Cell Biology, promise to open the door to new possibilities for drug development.

The work focuses on G protein-coupled receptors (GPCRs), a class of molecules in cell membranes that comprise the largest superfamily in the human genome. In spite of being the focus of roughly half of modern drug development due to their key role in signaling across the membrane, until now it has not been well understood how GPCRs relay signals from the outside world into cells' interiors.

For over 15 years, debate regarding GPCRs' signaling mechanisms has centered on whether these molecules work alone (as monomers) or in pairs (dimers). Using formyl-peptide receptors (FPRs) as a model GPCR, the research team found that the two views are both partially correct.

"By developing a super-quantitation single-molecule imaging method, in which GPCR molecules are inspected one by one in living cell membranes," explained Rinshi Kasai of Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and lead author of the paper, "we are now able to actually 'see' that each individual FPR molecule moves around in the cell membrane, endlessly interconverting between monomers and dimers with different partners, completing each cycle within a quarter of a second."

According to iCeMS Professor Akihiro Kusumi, "We obtained a parameter called the dissociation constant, which will allow us to predict numbers of monomers and dimers if the total number of GPCRs in a cell is known. The ability of scientists to obtain such key numbers will be essential for understanding GPCR signaling, as well as defects leading to diseases from the neuronal t
'/>"/>

Contact: Yutaka Iijima
yutaka-iijima@icems.kyoto-u.ac.jp
Institute for Integrated Cell-Material Sciences, Kyoto University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Expanding drug development horizons: Receptor behaviors observed in living cell membranes
2. Safe and Secure TV Channel Expanding Programming and Revenue Agreements for 2011 with Pentagons Military News Channel and other Security Industry Leaders
3. Oridion Signs New Distributor Agreement With IMI Expanding its Presence in the Japanese Market
4. San Diego Region Awarded $4 Million Workforce Development Grant to Support Expanding Biofuels Industry
5. No Economic Slowdown for Expanding U.S. Medical Manufacturer
6. SynCo Bio Partners Increases its Capacities by Expanding its Quality Team
7. Expanding Indianas Breakthroughs in Health Information Technology (Exibhit Indiana): Initiative to Advance the States Health IT National Leadership and Assets Launched to Bring More Awareness to Sector
8. Biomedical Sciences Companies Expanding in Asia Invested More Than US$500 Million in Singapore
9. Robust Annual Growth Through 2012 in the Age-Related Macular Degeneration Market Will Be Driven by Expanding Use of Lucentis in Europe
10. Rapidly Expanding Ohio Bioscience Industry Drives New Workforce Training Program
11. ViroPharma Enhances Leadership to Support Global Growth and Expanding Business
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Aug. 28, 2014  Next month, executives from clinical trial ... industry events beginning with Patient-Centered Clinical Trials 2014 , ... Boston , September 4-5. Patient recruitment experts ... Aaron Fleishman will share insights on the benefits of ... of tactics – from media to mobile apps – can ...
(Date:8/28/2014)... BELLINGHAM, Washington, USA (PRWEB) August 27, 2014 ... Colorado next month for SPIE Laser Damage 2014 ... on optical materials for high-power lasers will run 14-17 ... international society for optics and photonics . , The ... key for understanding laser damage to optical materials will ...
(Date:8/28/2014)... 28, 2014 Whitehouse Laboratories is excited ... partnership with PTI Inspection Systems that will ... of the art leak testing method development and validation ... currently available. As part of this agreement, Whitehouse Labs ... Leak Detection Instrument developed and manufactured by PTI. ...
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces ... available in its catalogue: Global ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About ... that are readily decomposed by the action ... non-degradable packaging in terms of raw materials, ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7
... Program -, LIONVILLE, Pa., Feb. 27 West Pharmaceutical,Services, ... of Directors,approved a second quarter 2008 cash dividend of $0.14 ... to shareholders of record on April 23,2008., The Company ... stock at an average price of $40.23 per share since ...
... Feb. 27 /Xinhua-PRNewswire-FirstCall/ --,Kiwa Bio-Tech Products Group Corporation ... considered as a supplier of bio-fertilizers,for the vegetable ... hotels,during the 2008 Olympics. Kiwa also announced that ... the Company, would participate in an interview with,WallSt.net ...
... PALO ALTO, Calif., Feb. 27 Telik, Inc.,(Nasdaq: ... or $0.25 per share,for the fourth quarter ended December ... or $0.34 per share, for the comparable period in ... total operating costs and,expenses were $13.5 million, compared with ...
Cached Biology Technology:Beijing 2008 Olympic Games Vegetable Supplier Considering Kiwa as a Supplier of Bio-Fertilizers & Kiwa Announces CEO Interview with WallSt.net 2Beijing 2008 Olympic Games Vegetable Supplier Considering Kiwa as a Supplier of Bio-Fertilizers & Kiwa Announces CEO Interview with WallSt.net 3Telik Announces Fourth Quarter and 2007 Year End Financial Results and 2008 Guidance 2Telik Announces Fourth Quarter and 2007 Year End Financial Results and 2008 Guidance 3Telik Announces Fourth Quarter and 2007 Year End Financial Results and 2008 Guidance 4
(Date:8/27/2014)... University of Utah biologist agan Sekercioglu, who campaigns to ... nation,s highest science prize, which is similar to the ... five researchers picked for 2014 the top awards by ... Three researchers won the Science Award and two ... equivalent to the Science Award but for scientists who ...
(Date:8/27/2014)... , Aug. 27, 2014 /PRNewswire-iReach/ -- The IEEE ... the 36 th Annual International Conference (EMBC,14), this ... Towers in Chicago, Illinois , from ... 2,500 global leaders, students, and industry professionals in science, ... Logo - http://photos.prnewswire.com/prnh/20140827/140333 This ...
(Date:8/27/2014)... number of consumers are willing to pay a premium ... whether they,re getting what the label claims is another ... devising a new way to make sure farms are ... ACS, Journal of Agricultural and Food Chemistry , ... the Bavarian Health and Food Safety Authority and the ...
Breaking Biology News(10 mins):University of Utah biologist wins Turkey's top science prize 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3
... While patients hospitalized for a heart attack have long ... analysis by researchers from the Duke Clinical Research Institute ... percent higher risk of dying. , The researchers call ... Meanwhile, they advise cardiologists to begin treatment with sufficient ...
... by fruit fly geneticists for more than a decade ... in mice. , Writing in the May 6 edition ... a streamlined method for creating a "genetic mosaic mouse"--a ... clusters of cells with mutated genes. , The new ...
... statistical method, described in the open-access journal PLoS Biology, ... locations in the genome that influence a particular physical ... by John Storey, Joshua M. Akey, and Leonid Kruglyak, ... them identify all the genomic elements that produce specific ...
Cached Biology News:Morphine for Chest Pain Increases Death Risk 2Morphine for Chest Pain Increases Death Risk 3Mosaic mouse technique offers a powerful new tool to study diseases and genetics 2Mosaic mouse technique offers a powerful new tool to study diseases and genetics 3Improved statistical tools reveal many linked loci 2
... locking design in ice/water bath This ... number, created to easily match Cornings ... yet, please order under the old ... service for assistance. ID clarifier: rack ...
... 2 Oligo Microarray Kit (V2), 22K is useful ... stress response. Each microarray contains content derived from ... for Genomic Research (TIGR) and represents 21,500 genes. ... standard 1 x 3? glass slides each containing ...
... With costs of poor quality ... pharmaceutical manufacturing organizations are under increasing ... In tablet production, the microscopic distribution ... important quality parameters such as dissolution, ...
... FLAG Immunoprecipitation kit allows a rapid ... an active FLAG-tagged protein. The immunoprecipitation ... which is a highly specific monoclonal ... The use of affinity resin allows ...
Biology Products: