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Exosome Diagnostics Presents Data at American Urology Association Demonstrating Potential Utility of Urine Exosomes to Non-invasively Detect and Manage Prostate Cancer
Date:5/23/2012

patients. The study also demonstrated a high level of concordance between exosome-biomarker signature and the marker's presence in cancerous prostate tissue. 

"The diagnosis and management of prostate cancer and patients with elevated PSA remains challenging for both patients and their physicians," said James McKiernan, M.D., the John and Irene Given professor of Urology, director of Urologic Oncology, Columbia University Medical Center and co-author of the study.  "Patients with high PSA results must decide whether to undergo a biopsy procedure, which in itself may not be definitive as further suggested from the results of the study.  A reliable, non-invasive diagnostic test that can determine the presence and nature of a prostate malignancy as well as its response to treatment would be of great value.  The biofluid-based technology highlighted in this study is a very promising approach to reaching this goal."

Lin et al. (abst. # 2232), investigated the relationship of survivin expression measured in exosomes and the disease status of patients diagnosed with CRPC. The presence of survivin, an inhibitor of apoptosis, has been implicated as a factor in hormone-independent tumor growth.  Survivin expression was higher in patients with measurable disease than in patients without disease and this was correlated with castration resistance. 

"Monitoring patient response to treatment is largely limited to PSA testing and new tools are needed," said Daniel Petrylak, M.D., associate professor of medicine, Columbia University Medical Center and co-author of the study.  "The non-invasive biofluid test we employed in this study directly measures one component of the genetic profile of malignant prostate cells.  This approach should enable us to better understand a patient's response to treatment and, if an alternative therapy is required, an analysis of exosome RNA and DNA content could better direct a treatment dec
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