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Exosome Diagnostics Presents Data at American Urology Association Demonstrating Potential Utility of Urine Exosomes to Non-invasively Detect and Manage Prostate Cancer
Date:5/23/2012

NEW YORK, May 23, 2012 /PRNewswire/ -- Exosome Diagnostics, a leading developer of biofluid-based molecular diagnostic tests for use in personalized and non-invasive cancer diagnostics, today presented two clinical studies demonstrating the potential utility of non-invasive sampling of patients' urine to detect and manage prostate cancer. 

In the first study, the presence of a prostate cancer-specific biomarker in exosomes collected from random patients' urine samples demonstrated a strong correlation to the presence of that marker in prostate tissue removed via radical prostatectomy (RP).  The study also correlated the expression level of the marker in urine with the likelihood of a positive cancer biopsy. 

In a second study, urinary exosomes demonstrated elevated levels of survivin messenger RNA (mRNA) from patients with castration-resistant prostate cancer (CRPC) following primary therapy.  Survivin expression has been implicated in hormone-independent prostate cancer growth.

"These studies, led by our director of research, Dr. Leileata Russo and conducted by our clinical collaborators, are part of our prostate cancer in vitro molecular diagnostics program," said James McCullough, chief executive officer of Exosome Diagnostics. "The urinary exosome provides us with a stable source of RNA that we can interrogate using qPCR to non-invasively analyze different stages of prostate cancer."  

Motamedinia et al. (abst. # 2108) obtained random samples of urine from men and measured the concordance of prostate cancer with detection of the biomarker, TMPRSS2:ERG (T:E).  The investigators found that TMPRSS2:ERG expression occurred in 17 of 21 post-RP tissue samples.  They also found that T:E expression in urinary exosomes from non-digital rectal exam (DRE) patients was nine-fold higher in the prostate biopsy positive patients versus biopsy negative
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