Navigation Links
Exosome Diagnostics Announces Additions to Management and Scientific Advisory Board as Company Expands Clinical Validation Studies in Oncology

NEW YORK, Oct. 4, 2011 /PRNewswire/ -- Exosome Diagnostics, a leading developer of biofluid-based molecular diagnostic tests for use in personalized medicine, today announced the appointment of David Okrongly, Ph.D., as chief operating officer, Michael Donovan, M.D., Ph.D., as chief medical officer, and Sally Bowden, Ph.D., as director of regulatory affairs.  Raphael Bueno, M.D., associate chief of cardiothoracic surgery Harvard University and Michael Manyak, M.D., FACS, executive director global medical affairs at GlaxoSmithKline were named to the Scientific Advisory Board.

The hiring of Drs. Okrongly, Donovan and Bowden reflect the Company's expanded research and clinical validation program for its proprietary exosome RNA biofluid technology in oncology diagnostics.  Exosome Diagnostics is applying the stable RNA content of blood and urine exosomes to develop in-vitro diagnostics for transcriptional disease profiling, patient stratification and disease monitoring in prostate cancer, melanoma and other cancers.  

"The collective professional experiences of Drs. Okrongly, Donovan and Bowden are invaluable management additions as we expand clinical studies for our lead exosome biofluid RNA diagnostics," said chief executive officer James McCullough. "The addition of Dr. Bueno and Dr. Manyak to our Scientific Advisory Board builds on our strategy of working closely with top clinical investigators to more accurately assess how exosome technology can be best applied to address unmet medical needs."    

Dr. Okrongly has significant experience developing and commercializing advanced diagnostic platforms.  Dr. Okrongly was president and chief executive officer of Quanterix from August 2009 to May 2011, leading the company in development of the first fully automated, single-molecule diagnostic platform with 1,000 times better sensitivity than ELISA. From May 1997 to December 2006, Dr. Okrongly was with Bayer Diagnostics (ETR:BAYN), where he was the leader of the global R&D organization, launching industry-leading platforms in immunoassay, hematology, clinical chemistry and molecular diagnostics. After the Siemens acquisition of Bayer Diagnostics in 2006, he was appointed senior vice president in charge of the Molecular Diagnostics Business Unit from January 2007 to August 2009. Prior experience includes vice president of R&D Xytronyx, a San Diego-based POC company from 1994-1997 and Applied Immune Sciences, a Santa Clara, CA stem cell therapy company, where he led product development from 1987 to 1994. During Dr. Okrongly's tenure, the company completed an IPO and was eventually acquired by Rhone Poulenc-Rorer (now Sanofi). He received his Bachelors degree from the University of Wisconsin-Madison and his Ph.D. from Columbia University, both in Chemistry.

Dr. Donovan is board certified in anatomic and clinical pathology and pediatric pathology with extensive experience designing and conducting clinical trials in melanoma and prostate cancer.  Prior to joining Exosome Diagnostics, he held positions as chief scientific officer for Aureon Biosciences, assistant professor at Harvard Medical School, senior director of Molecular Pathology at Millennium Pharmaceuticals, and senior vice president at Incyte Genomics. At Millennium, he was involved with the clinical development of Velcade®, the first proteasome inhibitor approved for clinical use. He also contributed to the expanded of use of Tarceva in glioblastoma multiforme, and the development of Iressa in non-small cell lung cancer.  Dr. Donovan received his M.D. from the University of Medicine and Dentistry of New Jersey, and his Ph.D. in cell and developmental biology from Rutgers University. Dr. Donovan has recently joined the faculty at Mt. Sinai School of Medicine as a Professor in the Department of Pathology and Genetics and will also serve as director of Experimental Pathology.

Dr. Bowden has over 20 years of experience in the quality and regulatory field in medical devices, companion diagnostics, education and health care systems.  She has served in executive positions as vice president of Quality Systems and Process Improvement at Ventana Medical Systems and as vice president of Quality and Regulatory Compliance at Roche Diagnostics Corporation.  She was an associate professor for Purdue University School of Engineering and Technology where she developed the Quality Management Curriculum within the Mechanical Engineering Technology department.  Dr. Bowden founded Samco & Associates, Inc in 2009 to provide consulting for companies interested in developing quality systems that meet FDA and global requirements and re-engineer them for efficient, effective compliance in the medical device field for all classes. In addition, Dr. Bowden is helping to pioneer the Companion Diagnostic process in collaboration with pharmaceutical and diagnostic firms while building strong relationships with the applicable regulatory agencies.  Dr. Bowden is a graduate of Purdue University School of Engineering.  

Dr. Raphael Bueno is a professor of surgery at Harvard Medical School and associate chief of thoracic surgery, Director of the Thoracic Intermediate Care Unit, director of the Thoracic Surgery Training Program, and director of the Photodynamic Therapy Program at Brigham and Women's Hospital. Dr. Bueno joined the Division of Surgery at Brigham and Women's Hospital in 1996. Having graduated from Harvard University and Harvard Medical School, he completed his surgery residency at BWH and Massachusetts General Hospital. His clinical interests include tracheal surgery, lung cancer, mesothelioma, esophageal cancer, benign esophageal disorders, thymomas and minimally invasive surgery. His research interest is in the area of genomic research in thoracic cancers, primarily to better characterize the behavior of lung cancers and mesothelioma at the molecular level and to utilize this information in order to design novel diagnostic and therapeutic modalities. Dr. Bueno is a member of the American Association for Thoracic Surgery (AATS), the Cardiothoracic Surgery Network (CSN), the European Society of Thoracic Surgeons (ESTS), the General Thoracic Surgical Club (GTSC), and the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) and The Society of Thoracic Surgeons (STS). Dr. Bueno also serves on the Editorial Board of the Journal of Thoracic and Cardiovascular Surgery (JTCVS).

Dr. Michael J. Manyak is executive director of Global Medical Affairs for the urology franchise at GlaxoSmithKline (LON:GSK) and professor of Urology, Engineering, Microbiology, and Tropical Medicine at The George Washington University. He has served as board member, consultant, or director to more than 25 biotechnology and pharmaceutical firms. He is a founder of Metastatin Pharmaceuticals, purchased by Samaritan Pharmaceuticals. Dr. Manyak has been granted 11 patents and has several pending. He served on the Imaging Subcommittee of the Medicare Coverage Advisory Committee for the Center for Medicare and Medicaid Services. He received a presidential appointment to the National Kidney and Urological Disease Advisory Board. He has served twice as a voting member of the FDA Regulatory Panel for Genitourinary and Gastrointestinal Devices. Dr. Manyak served as Chairman of the American Urological Association (AUA) Technology Assessment Council and on five other AUA committees related to technology. He has published nearly 200 professional abstracts, book chapters, and refereed journal articles.

About Exosome Diagnostics
Exosome Diagnostics is a leading developer of biofluid based molecular diagnostic tests for use in personalized medicine. Exosomes are shed into all biofluids, including blood, urine, and CSF, forming a stable source of intact, disease-specific nucleic acids. The Company's proprietary exosome technology makes use of this natural stability to achieve high sensitivity for rare gene transcripts and the expression of genes responsible for cancers and other diseases. The Company is commercializing in vitro diagnostic tests for use in companion diagnostic applications and real-time monitoring of disease. The Company maintains facilities in New York, St. Paul, MN and Munich, Germany. For more information, please visit

SOURCE Exosome Diagnostics
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Aethlon Medical Appoints Jeff Schorey and Wayne Comper to Exosome Sciences Advisory Board
2. Exosome Diagnostics Appoints Former Roche Executive Greg Zdechlik as Chief Operating Officer
3. Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations
4. Exosome Diagnostics Appoints Johan Skog, Ph.D., as Director of Genetics Research
5. Exosome Diagnostics Announces Additions to Management Team
6. Ambry Genetics First to Offer Exome Sequencing Service for Clinical Diagnostics.
7. SuperNova Diagnostics® to Present at AdvaMed 2011: The Medtech Conference in Washington, D.C.
8. The New Face of Personalized Medicine: Targeting Disease Diagnostics and Treatments with Big Data Analytics: October 6, 2011, 1 PM EDT, Webinar
9. Eric Tornoe Joins Exagen Diagnostics as President and COO
10. ReportsnReports - Needle-Free Drug Delivery Market & Hospital-Acquired Infections (HAI) Diagnostics Market Reports
11. Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities
Post Your Comments:
(Date:4/20/2017)... ... April 20, 2017 , ... NetDimensions appoints Bill Mastin, ... With over 20 years of experience in the learning technologies industry, Mastin joins NetDimensions ... within Learning Technologies Group plc (LTG). At LEO, Mastin served as SVP of the ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... for advanced technology applications, announced today that Chief Executive Officer (CEO) Debbie Gustafson ... SEMI is the global industry association connecting the electronics manufacturing supply chain. ...
(Date:4/20/2017)... Bethesda, MD (PRWEB) , ... April 20, 2017 ... ... announce the formation of a unique intellectual property (IP) sharing and commercialization model. ... their most promising inventions. A main component of this effort is bringing the ...
(Date:4/20/2017)... N.J. and PETACH TIKVAH, Israel ... BCLI), a leading developer of adult stem cell technologies for ... Executive Officer, will present at the Alliance for Regenerative Medicine,s ... Day on Thursday, April 27, 2017 at 09:40 EDT in ... Ralph Kern , MD, MHSc, Chief Medical Officer & ...
Breaking Biology Technology:
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced ... Analysis & Trends - Industry Forecast to 2025" report to ... The ... a CAGR of around 15.1% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
(Date:3/22/2017)... 2017 Optimove , provider of ... such as 1-800-Flowers and AdoreMe, today announced two ... Replenishment. Using Optimove,s machine learning algorithms, these features ... replenishment recommendations to their customers based not just ... customer intent drawn from a complex web of ...
Breaking Biology News(10 mins):