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ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results
Date:3/3/2009

07.

- Cash flow statements

In 2008, ExonHit's net use of cash due to operating activities was EUR 9.6 million compared to EUR 4.9 million in 2007. This difference is mainly due to the increased operating losses and to the increased Research Tax Credit line.

The equipment necessary to strengthen our service laboratory and prepare it for GLP mainly explains the capital expenditure level of EUR 1.2 million in 2008, compared to EUR 1.1 million in 2007.

Due to unfavorable market conditions, financial operations generated EUR 0.2 million in 2008, to be compared with the generation of EUR 13.3 million in 2007.

Product Update

- Diagnostics

EHT Dx21, our internally developed blood diagnostic test for Alzheimer's disease (AD), is undergoing clinical validation. The clinical study EHT AD/002 initiated early in 2008 to recruit blood samples for patients suffering from AD, other dementias and controls achieved its first goal with the recruitment of 311 samples in Q3 2008. The second part of the study was initiated in January 2009 with the recruitment of 250 additional samples making the total number of samples included in the validation the largest for an array based AD blood diagnostic test.

Assuming successful clinical validation, ExonHit Therapeutics plans to launch EHT Dx21 as a Research Use Only product in the clinical trial market in Q4 2009, and in the clinical diagnostic market in a second step through a partnering model.

In February 2009, bioMerieux and ExonHit Therapeutics agreed on new research and development plans as part of their existing collaboration to develop blood-based cancer detection biomarkers. Both companies are jointly pursuing their programs on colorectal and prostate cancers (respectively EHT Dx12 and EHT Dx13) using ExonHit's next generation of human genome-wide SpliceArray(tm) biochips for biomarker disco
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SOURCE ExonHit Therapeutics SA
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Related biology technology :

1. ExonHit is Honoured by the "Innovation Trophy" From The National Institute of Industrial Property (INPI)
2. ExonHit Launches Mouse Genome SpliceArray(TM) for use in Human Disease Modeling Studies
3. Loic Maurel Joins Exonhit Therapeutics to Become CEO
4. ExonHit Launches Rat Genome SpliceArray(TM) Products to Expand High Resolution Gene Expression Profiling for use in Disease Modeling and Toxicogenomics
5. Frederic Desdouits Appointed Member of the Supervisory Board of ExonHit Therapeutics
6. ExonHit Appoints a New Management Board
7. ExonHit Therapeutics - 2007 Financial Results
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9. ExonHit and bioMerieux Amend Their Strategic Partnership
10. ExonHit Gets Regulatory Approval to Initiate a Phase 2 Clinical Trial for EHT 0202 in Alzheimers Disease
11. ExonHit Completes a Prototype to Detect Alzheimers Disease From Blood
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