Navigation Links
Exit discovered in cellular garbage truck
Date:5/10/2013

At the University of Geneva (UNIGE), the team led by Professor Jean Gruenberg has long been interested in the movement of lysosomes, the sub-compartments of cells to where endocytic vesicles deliver their waste content and the molecules destined to be destroyed. Within this context, researcher Christin Bissig, along with her international colleagues, carried out a detailed study of the route taken by Alix which is lodged inside the endosomal membrane. This tailing has highlighted how protein contributes to avoiding cellular digestion, like a door opening into the endosomal transporter garbage bin, bringing about a final waste sorting operation which determines the cell's health. The researchers also showed how vesicular stomatitis makes use of the same route to penetrate the inside of the cell and infect it.

Finally, they identified a lipid, partnered with Alix in this process and present only in the late endosome. This is the first characterisation of the protein-lipid partnership throughout the atom.

Refuse collection and the path of life

Endosomes and lysosomes are 0.2 to 0.5 cell organelles and are present in all animal cells. Their role is to sort molecules and ensure inter-cell digestion and regulation. In all eukaryotes from yeast to human, they carry then transform or destroy proteins, lipids or sugars which the cell feeds on in order to grow and regenerate. In a certain number of diseases or conditions, lysosomes and endosomes are reached and they no longer carry out their transport or degradation work. This is particularly the case with people suffering from lysosomal diseases. The cells are then clogged with waste. The organism is deregulated, even intoxicated. This path taken by these essential refuse collectors therefore merits greater recognition and documentation.

Lodged inside the endosomes, the Alix protein takes this same route, known as endocytosis, where molecules and particles travel from the external cell membrane to the cell's interior. Through this in-depth study biochemists have, without knowing it, opened up fresh applied research perspectives, relating particularly to the worst forms of cholesterol: that which accumulates in lysosomes and endosomes.

Biomedical perspectives

Contributing to the understanding of cholesterol transport - the good, the bad and the most damaging - and mapping out a pathway through which a number of viruses surge; such are the contributions of this fundamental research.

These observations are the focus of a publication in the next edition of online journal Development Cell.


'/>"/>

Contact: Jean Gruenberg
jean.gruenberg@unige.ch
41-223-796-464
Universit de Genve
Source:Eurekalert

Related biology technology :

1. A Mutation Discovered in Iceland that Increases Risks of Osteoporosis and Certain Cancers
2. Undiscovered Companies Announces A Video Interview Of Hidden Bio-Tech Company Immunotech Laboratories
3. New Way to Kill Bed Bugs Discovered; Bed Bug Bully Says Use of Bed Bug Spray Remains the Better Technique to Kill the Pests
4. Millions of DNA switches that power human genomes operating system are discovered
5. Discovered Evolution of Genomic Sequences -- from Ocean Archaea to Brain Cancer -- Leads to New Synthetic Replikin Vaccines for Infectious Diseases and Cancer
6. Australian Discovered Biomarkers Map Path to New Blood Test for Bowel Cancer
7. Novel method to make nanomaterials discovered
8. Dual-acting class of antimalarial compounds discovered with potential to prevent and treat malaria
9. ASGCT Annual Meeting to Highlight Latest Advances in Genetic and Cellular Therapeutics
10. Cellular Biomedicine Group Provides Update and 2013 Milestones
11. Unique Extracellular Matrix Used in Patient Successfully Treated for Flesh Eating Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... 2016  Global demand for enzymes is forecast ... to $7.2 billion.  This market includes enzymes used ... biofuel production, animal feed, and other markets) and ... Food and beverages will remain the largest market ... of products containing enzymes in developing regions.  These ...
(Date:6/27/2016)... Raleigh, NC (PRWEB) , ... June 27, 2016 ... ... a mission to bring innovative medical technologies, services and solutions to the healthcare ... development and implementation of various distribution, manufacturing, sales and marketing strategies that are ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
Breaking Biology Technology:
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
Breaking Biology News(10 mins):