Navigation Links
Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer
Date:9/4/2007

tation, and 3 were EGFR wild-type.

-- All 6 patients with EGFR-activating mutations demonstrated clinical

benefit (5 PR, 1 SD).

-- XL647 is generally well tolerated in this patient population. The most

frequently reported adverse events assessed as being related to XL647

were diarrhea, rash, fatigue, and nausea, all of which were Grade 1 or

Grade 2 in severity.

"The data reported today demonstrate that XL647 has potential utility in patient populations with both mutated and wild-type EGFR," said Dr. Shirish Gadgeel of Karmanos Cancer Institute at Wayne State University. "Importantly, the data highlight that patients to date appear to have milder EGFR-related side-effects -- rash and diarrhea -- than previously described with other EGFR inhibitors while retaining potent anti-tumor activity with durable responses and stable disease. Although these are early results, they provide a compelling rationale for expediting the full development of XL647 in non-small cell lung cancer."

"These data suggest that XL647 has the potential for utility in patients with NSCLC who have an activating EGFR mutation and those with wild-type EGFRs. We believe these data support an aggressive clinical development strategy in first, second and third-line treatment as both a single agent and in combination with other therapies," said George A. Scangos, Ph.D., president and chief executive officer of Exelixis. "Moreover, new data from an ongoing phase 1 trial of XL647 suggest that daily dosing results in higher drug concentrations than those observed to date in this phase 2 study with intermittent dosing. We expect to complete this evaluation of both daily and intermittent dosing schedules soon in order to select the optimal regimen and dose for the late-stage development of XL647."

The most frequently reported treatment-related adverse events (AEs) were Grade 1 and 2 diarrhea and fatigue, and Grade 1 nausea and rash. Six pat
'/>"/>

SOURCE Exelixis, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. TomoTherapy reports 86% revenue jump, $131M net loss in Q1
2. Sonic Foundry reports GAAP loss as Q2 revenues rise
3. Fiserv reports $113.5 million in Q1 profit
4. Third Wave reports net loss of $18.9M for 2006
5. Musicnotes reports 45 percent growth in 2006
6. Sonic Foundry reports net loss, higher revenue
7. Sonic Foundry reports first cash-positive quarter
8. Merge Healthcare reports $10.8M net loss in Q3
9. Third Wave reports $5.2M third quarter loss
10. Merge Healthcare appoints new CEO, reports $215 million Q2 loss
11. Merge files financial reports by market opening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
(Date:1/15/2014)... Look inside the new Preferred Solutions® catalog ... from fluid handling to instruments to supplies. Many items ... order. , Preferred Solutions features a full selection ... model for precise flow control and dispensing to I/P® ...
Breaking Biology Technology:Even geckos can lose their grip 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2
... peak in interest? And what do Xers care about? , ... finally. Today, 27 and 25 are the average ages of ... means pushing back adult realities and concerns. When a young ... Its just taken Xers a little longer to get there. ...
... has become a booming export business. Universities are expanding offshore ... from Asia, the South Pacific and the Middle Eastwho are ... education demand is so strong that sale of academic sheepskins ... lessons learned in the land down under should be noted ...
... to a close, the fourth quarter represents a fast and furious ... more important of these events: , , , ,Eleven ... activities! This is a good sign and bodes well for the ... Chicago. Its also an indicator that biotech is alive, prospering and ...
Cached Biology Technology:Presidential politics and the next generation 2Wisconsin can teach the world, and profit by it 2Wisconsin can teach the world, and profit by it 3Furious pace of Midwest biotech events marks progress 2Furious pace of Midwest biotech events marks progress 3
(Date:7/10/2014)... the main organization of the International Science and Business ... group of researchers, led by professor Won Do Heo, ... optogenetics that can remotely control specific receptors by light. ... has succeeded with neuronal differentiation inducement. , The most ... only light to activate neuronal functions without the need ...
(Date:7/10/2014)... vegetable oil found in your popcorn or soap might not ... even worse, according to an analysis in the Cell Press ... growing demand for vegetable oil has already led to the ... trouble for orangutans in particular. If guidelines are not put ... large-scale industrial plantations from Asia into Africa will be bad ...
(Date:7/10/2014)... the open ocean as a microbial megacity, teeming with ... of water, hundreds of types of bacteria can be ... these ocean microbes have their own daily cyclesnot unlike ... wake up, commute, work, and eat at the same ... Light-loving photoautotrophsbacteria that need solar energy to help them ...
Breaking Biology News(10 mins):New optogenetic tool for controlling neuronal signalling by blue light 2Hunger for vegetable oil means trouble for Africa's great apes 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3
... Science Translational Medicine announces the addition of twelve ... as Associate Scientific Advisors for the journal. Starting mid-January, ... and consult with Science Translational Medicine editors ... "The Science Translational Medicine editors selected these ...
... spend billions of dollars each year on exotic smelling perfumes ... according to a new study in Psychological Science , ... natural" may be the best way to capture a potential ... animal mating habits: Animal studies have shown that male testosterone ...
... Neuroscience Programme at the IGC, has become one of ... competitive European Research Council grants, to the value of ... This grant, which recognises Mainen,s contribution to the Neuroscience ... of the neurotransmitter serotonin. The ERC is the most ...
Cached Biology News:Science Translational Medicine adds 12 new associate scientific advisors 2
... Salmonella genomes has allowed the development of ... pairs. The S. enterica Typhimurium (strain LT2) ... bp; 4,440 ORFs) and a plasmid, pSLT ... Sigma-Genosys have been designed to amplify all ...
... The Bio-Stack Twister II Microplate ... top automation solution for integrating BioTeks ... together with expandable microplate capacity, ultimate ... Whether you are adding capacity to ...
XPLAC (S-17)...
Request Info...
Biology Products: